Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.70 |
| ▸ | MAPT | P10636 | 9/20 | 0.68 |
| ▸ | LMNA | P02545 | 4/20 | 0.66 |
| ▸ | TP53 | P04637 | 1/20 | 0.65 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.62 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.62 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.62 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.62 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.62 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.62 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.62 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.62 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.62 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.62 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.62 |
| ▸ | MEN1 | O00255 | 3/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.62 |
| ▸ | RAB9A | P51151 | 2/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1617706 | 0.94 | KDM4E (0.68) | HPGDMAPTLMNAHDAC1HDAC6 | |
| SCHEMBL5374706 | 0.94 | KDM4E (0.68) | HPGDMAPTLMNAHDAC1HDAC6 | |
| SCHEMBL6859665 | 0.92 | HPGD (0.73) | HPGDMAPTLMNATP53HDAC1 | |
| SCHEMBL6647151 | 0.89 | HPGD (0.89) | HPGDMAPTLMNATP53HDAC1 | |
| SCHEMBL4881421 | 0.88 | LMNA (0.71) | HPGDMAPTLMNATP53HDAC1 | |
| SCHEMBL108118 | 0.88 | LMNA (0.71) | HPGDMAPTLMNATP53HDAC1 | |
| SCHEMBL14148886 | 0.88 | L3MBTL1 (0.70) | HPGDMAPTLMNATP53HDAC1 | |
| SCHEMBL29356447 | 0.88 | L3MBTL1 (0.70) | HPGDMAPTLMNATP53HDAC1 | |
| SCHEMBL6856497 | 0.88 | L3MBTL1 (0.70) | HPGDMAPTLMNATP53HDAC1 | |
| Zanthomamide SCHEMBL29407211 | 0.85 | MAPT (0.87) | HPGDMAPTLMNATP53HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6831080-B2 | E.g., 3-(2-fluorophenyl)-N-(1-(3-morpholin-4-yl)phenyl)-propyl)acrylamide; disorders responsive to opening of KCNQ potassium channels; analgesics; migraine, bipolar disorders, anticonvulsants, antiepileptic, anxiolytic agents | BRISTOL-MYERS SQUIBB COMPANY | 2004-12-14 | — | — | US | disclosed |