Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 1/20 | 0.40 |
| ▸ | HTR2B | P41595 | 1/20 | 0.40 |
| ▸ | HTR7 | P34969 | 1/20 | 0.39 |
| ▸ | PDE7A | Q13946 | 2/20 | 0.36 |
| ▸ | AR | P10275 | 1/20 | 0.36 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 4/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | CMKLR1 | Q99788 | 1/20 | 0.32 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.32 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.32 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.32 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL292402 | 0.91 | AR (0.39) | OPRM1HTR2BHTR7ARMEN1 | |
| SCHEMBL293635 | 0.82 | RECQL (0.40) | OPRM1HTR7ARP2RX7MEN1 | |
| SCHEMBL291655 | 0.80 | MEN1 (0.40) | OPRM1HTR7ARMEN1KMT2A | |
| SCHEMBL292960 | 0.78 | MEN1 (0.53) | OPRM1ARMEN1KMT2AALDH1A1 | |
| SCHEMBL294226 | 0.77 | DDB1 (0.49) | OPRM1P2RX7MEN1KMT2AALDH1A1 | |
| SCHEMBL291850 | 0.73 | OPRM1 (0.49) | OPRM1ARMEN1KMT2AALDH1A1 | |
| SCHEMBL291894 | 0.72 | MAPT (0.43) | OPRM1HTR2BHTR7MEN1KMT2A | |
| SCHEMBL292828 | 0.72 | HTR7 (0.40) | HTR7ARP2RX7 | |
| SCHEMBL291908 | 0.72 | HTR7 (0.40) | OPRM1HTR7ARP2RX7MEN1 | |
| SCHEMBL292131 | 0.72 | AR (0.43) | ARMEN1KMT2APOLBGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011065519-A1 | SUBSTITUTED OXOPIPERAZINE COMPOUND | 第一三共株式会社 (JP) | 2011-06-03 | — | — | WO | disclosed |