Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 7/20 | 1.00 |
| ▸ | GRIN2D | O15399 | 6/20 | 1.00 |
| ▸ | GRIN3B | O60391 | 6/20 | 1.00 |
| ▸ | GRIN1 | Q05586 | 6/20 | 1.00 |
| ▸ | GRIN2A | Q12879 | 6/20 | 1.00 |
| ▸ | GRIN2B | Q13224 | 6/20 | 1.00 |
| ▸ | GRIN2C | Q14957 | 6/20 | 1.00 |
| ▸ | GRIN3A | Q8TCU5 | 6/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | THRA | P10827 | 1/20 | 0.48 |
| ▸ | THRB | P10828 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 3/20 | 0.48 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | EBP | Q15125 | 1/20 | 0.48 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8996665 | 0.97 | SIGMAR1 (1.00) | SIGMAR1GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL6719092 | 0.85 | SIGMAR1 (0.78) | SIGMAR1GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL6719066 | 0.84 | SIGMAR1 (0.76) | SIGMAR1GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL6720731 | 0.82 | SIGMAR1 (0.73) | SIGMAR1GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL6716543 | 0.82 | SIGMAR1 (0.73) | SIGMAR1GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL6717187 | 0.77 | SIGMAR1 (0.66) | SIGMAR1GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL2357753 | 0.76 | ALDH1A1 (0.63) | SIGMAR1GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL4512663 | 0.76 | SIGMAR1 (0.61) | SIGMAR1GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL17894510 | 0.76 | SIGMAR1 (0.61) | SIGMAR1GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL9293172 | 0.76 | SIGMAR1 (0.65) | SIGMAR1GRIN2DGRIN3BGRIN1GRIN2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6787569-B1 | INHIBITORS OF NEUROTRANSMITTER (E.G., GLUTAMATE) RELEASE FROM ISCHEMIC NEURONAL CELLS; N,N-DISUBSTITUTED GUANIDINES; NEUROLOGICAL CONDITIONS SUCH AS EPILEPSY, NEURODEGENERATIVE CONDITIONS AND/OR NERVE CELL DEATH FROM STROKE OR HEART ATTACK | CAMBRIDGE NEUROSCIENCE, INC. | 2004-09-07 | — | — | US | disclosed |