Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNQ2 | O43526 | 2/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.56 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | ACACB | O00763 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | GPER1 | Q99527 | 1/20 | 0.36 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.35 |
| ▸ | MEF2D | Q14814 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6858570 | 1.00 | KCNQ2 (0.56) | KCNQ2CYP3A4KCNQ3CYP1A2CYP19A1 | |
| SCHEMBL6858567 | 1.00 | KCNQ2 (0.56) | KCNQ2CYP3A4KCNQ3CYP1A2CYP19A1 | |
| SCHEMBL6858573 | 1.00 | KCNQ2 (0.56) | KCNQ2CYP3A4KCNQ3CYP1A2CYP19A1 | |
| SCHEMBL6858584 | 0.90 | KCNQ2 (0.57) | KCNQ2CYP3A4KCNQ3CYP1A2CYP19A1 | |
| SCHEMBL6859588 | 0.89 | KCNQ2 (0.51) | KCNQ2CYP3A4KCNQ3CYP1A2CYP19A1 | |
| SCHEMBL6855734 | 0.88 | KCNQ2 (0.59) | KCNQ2CYP3A4KCNQ3CYP1A2CYP19A1 | |
| SCHEMBL6649225 | 0.86 | KCNQ2 (0.49) | KCNQ2CYP3A4KCNQ3CYP1A2CYP19A1 | |
| SCHEMBL6649229 | 0.86 | KCNQ2 (0.49) | KCNQ2CYP3A4KCNQ3CYP1A2CYP19A1 | |
| SCHEMBL6649232 | 0.86 | KCNQ2 (0.49) | KCNQ2CYP3A4KCNQ3CYP1A2CYP19A1 | |
| SCHEMBL6646023 | 0.81 | CYP3A4 (0.72) | KCNQ2CYP3A4KCNQ3CYP1A2CYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6831080-B2 | E.g., 3-(2-fluorophenyl)-N-(1-(3-morpholin-4-yl)phenyl)-propyl)acrylamide; disorders responsive to opening of KCNQ potassium channels; analgesics; migraine, bipolar disorders, anticonvulsants, antiepileptic, anxiolytic agents | BRISTOL-MYERS SQUIBB COMPANY | 2004-12-14 | — | — | US | disclosed |
| US-20030166650-A1 | Cinnamide derivatives as KCNQ potassium channel modulators | BRISTOL-MYERS SQUIBB COMPANY | 2003-09-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030166650-A1 | Cinnamide derivatives as KCNQ potassium channel modulators | KCNH2, KCNH3, KCNQ1 | KCNQ2 6/4885CYP3A4 543/4885KCNQ3 11/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.