Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 1/20 | 0.61 |
| ▸ | DRD4 | P21917 | 1/20 | 0.61 |
| ▸ | CCR2 | P41597 | 12/20 | 0.61 |
| ▸ | TEAD1 | P28347 | 1/20 | 0.59 |
| ▸ | GAA | P10253 | 1/20 | 0.58 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.57 |
| ▸ | BCHE | P06276 | 1/20 | 0.56 |
| ▸ | ACHE | P22303 | 1/20 | 0.56 |
| ▸ | BACE1 | P56817 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27811320 | 0.87 | DRD4 (0.67) | DRD2DRD4SIGMAR1BCHEACHE | |
| SCHEMBL27811321 | 0.87 | DRD4 (0.67) | DRD2DRD4SIGMAR1BCHEACHE | |
| SCHEMBL22716940 | 0.87 | DRD2 (0.66) | DRD2DRD4CCR2TEAD1SIGMAR1 | |
| SCHEMBL4846218 | 0.86 | CCR2 (0.65) | DRD2DRD4CCR2TEAD1SIGMAR1 | |
| SCHEMBL4426840 | 0.86 | CCR2 (0.65) | DRD2DRD4CCR2TEAD1SIGMAR1 | |
| SCHEMBL4426833 | 0.86 | CCR2 (0.65) | DRD2DRD4CCR2TEAD1SIGMAR1 | |
| SCHEMBL4844836 | 0.84 | CCR2 (0.71) | DRD2DRD4CCR2SIGMAR1 | |
| SCHEMBL4847367 | 0.84 | CCR2 (0.71) | DRD2DRD4CCR2SIGMAR1 | |
| SCHEMBL4840672 | 0.83 | CCR2 (0.57) | DRD2DRD4CCR2TEAD1SIGMAR1 | |
| SCHEMBL4840662 | 0.83 | CCR2 (0.57) | DRD2DRD4CCR2TEAD1SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1448566-A2 | CHEMOKINE RECEPTOR ANTAGONISTS AND METHODS OF USE THEREOF | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2004-08-25 | — | — | EP | disclosed |
| WO-2003045942-A2 | CHEMOKINE RECEPTOR ANTAGONISTS AND METHODS OF USE THEREOF | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2003-06-05 | — | — | WO | disclosed |