Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 12/20 | 0.55 |
| ▸ | ADORA1 | P30542 | 11/20 | 0.55 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.43 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | CD38 | P28907 | 1/20 | 0.39 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.38 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.38 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.38 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.38 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6859554 | 0.88 | ADORA2A (0.54) | ADORA2AADORA1ADORA2BPOLB | |
| SCHEMBL6852677 | 0.81 | ADORA2A (0.57) | ADORA2AADORA1ADORA2BCD38 | |
| SCHEMBL6859692 | 0.81 | ADORA2A (0.57) | ADORA2AADORA1ADORA2BCD38 | |
| SCHEMBL6852672 | 0.81 | ADORA2A (0.57) | ADORA2AADORA1ADORA2BCD38 | |
| SCHEMBL6859506 | 0.78 | ADORA2A (0.62) | ADORA2AADORA1ADORA2B | |
| SCHEMBL6859687 | 0.77 | ADORA2A (0.58) | ADORA2AADORA1ADORA2B | |
| SCHEMBL6859543 | 0.77 | ADORA2A (0.64) | ADORA2AADORA1ADORA2B | |
| SCHEMBL6858307 | 0.76 | ADORA2A (0.56) | ADORA2AADORA1ADORA2B | |
| SCHEMBL6852934 | 0.76 | ADORA2A (0.56) | ADORA2AADORA1ADORA2B | |
| SCHEMBL6859739 | 0.74 | ADORA2A (0.59) | ADORA2AADORA1ADORA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6787541-B1 | MOVEMENT DISORDERS, PARKINSON'S DISEASE | VERNALIS RESEARCH LIMITED (GB) | 2004-09-07 | — | — | US | disclosed |