Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR1 | P32246 | 1/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.33 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.33 |
| ▸ | DRD2 | P14416 | 3/20 | 0.33 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.32 |
| ▸ | DRD4 | P21917 | 2/20 | 0.32 |
| ▸ | HRH2 | P25021 | 2/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.32 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.32 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.32 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.32 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.32 |
| ▸ | HRH1 | P35367 | 1/20 | 0.32 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | CES2 | O00748 | 1/20 | 0.32 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL655073 | 0.95 | CCR1 (0.37) | CCR1OPRM1OPRL1DRD2ADRA2A | |
| SCHEMBL653476 | 0.94 | OPRM1 (0.35) | CCR1OPRM1OPRL1DRD2ADRA2A | |
| SCHEMBL656410 | 0.93 | DRD2 (0.35) | CCR1OPRM1OPRL1DRD2DRD4 | |
| SCHEMBL654351 | 0.92 | CCR1 (0.35) | CCR1OPRM1OPRL1DRD2ADRA2A | |
| SCHEMBL654271 | 0.91 | CCR1 (0.34) | CCR1OPRM1OPRL1DRD2 | |
| SCHEMBL653005 | 0.89 | CCR1 (0.35) | CCR1OPRM1OPRL1DRD2 | |
| SCHEMBL653214 | 0.88 | OPRM1 (0.35) | CCR1OPRM1OPRL1DRD2ADRA2A | |
| SCHEMBL655209 | 0.88 | DRD2 (0.34) | CCR1OPRM1OPRL1DRD2ADRA2A | |
| SCHEMBL654228 | 0.88 | OPRM1 (0.36) | CCR1OPRM1OPRL1DRD2ADRA2A | |
| SCHEMBL654382 | 0.88 | DRD2 (0.35) | CCR1OPRM1OPRL1DRD2ADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1448566-A2 | CHEMOKINE RECEPTOR ANTAGONISTS AND METHODS OF USE THEREOF | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2004-08-25 | — | — | EP | disclosed |
| WO-2003045942-A2 | CHEMOKINE RECEPTOR ANTAGONISTS AND METHODS OF USE THEREOF | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2003-06-05 | — | — | WO | disclosed |