Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 11/20 | 0.54 |
| ▸ | ESR2 | Q92731 | 9/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.47 |
| ▸ | AR | P10275 | 6/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | BLM | P54132 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9519936 | 0.85 | ESR1 (0.59) | ESR1ESR2LMNAHSD17B10AR | |
| SCHEMBL9519856 | 0.84 | MAPT (0.55) | ESR1ESR2LMNAHSD17B1AR | |
| SCHEMBL9517557 | 0.83 | ESR1 (0.68) | ESR1ESR2LMNAHSD17B10HSD17B1 | |
| SCHEMBL6859059 | 0.81 | ESR1 (0.68) | ESR1ESR2LMNAHSD17B10AR | |
| SCHEMBL6462853 | 0.81 | LMNA (0.62) | ESR1ESR2LMNAHSD17B10AR | |
| SCHEMBL9517523 | 0.81 | ESR1 (0.73) | ESR1ESR2LMNAHSD17B10HSD17B1 | |
| SCHEMBL6852292 | 0.79 | ESR1 (0.68) | ESR1ESR2LMNAHSD17B10AR | |
| SCHEMBL9519844 | 0.79 | ESR1 (0.68) | ESR1ESR2LMNAHSD17B10AR | |
| SCHEMBL9516009 | 0.79 | ESR1 (0.68) | ESR1ESR2LMNAHSD17B10AR | |
| SCHEMBL6857433 | 0.79 | ESR1 (0.68) | ESR1ESR2LMNAHSD17B10AR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6790971-B1 | AMIDE OR CARBAMATE FUNCTION AT 11 BETA-POSITION; CLAIMED 3-ONE-DIENE INTERMEDIATE HAS HYDROXYMETHYLALKYL GROUP ON 11 POSITION; ANTIPROGESTOMIMETIC; HORMONE-DEPENDENT TUMORS; ANIMAL HUSBANDRY | AVENTIS PHARMA S.A. (FR) | 2004-09-14 | — | — | US | disclosed |
| US-5707982-A | ANTITUMOR | ROUSSEL UCLAF (FR) | 1998-01-13 | — | — | US | disclosed |
| US-5290771-A | 19-nor-steroids | ROUSSEL UCLAF (FR) | 1994-03-01 | — | — | US | disclosed |
| US-5149696-A | Antiestrogens | ROUSSEL UCLAF (FR) | 1992-09-22 | — | — | US | disclosed |