Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | LTA4H | P09960 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.43 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.43 |
| ▸ | LDHA | P00338 | 1/20 | 0.42 |
| ▸ | TOP2A | P11388 | 1/20 | 0.41 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2817244 | 0.85 | ALOX15 (0.62) | ALOX15NPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL6860229 | 0.83 | PTGS1 (0.63) | NPC1RAB9ASMN1; SMN2ALDH1A1POLB | |
| SCHEMBL2815127 | 0.83 | ALOX15 (0.59) | ALOX15NPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL2815756 | 0.82 | ALOX15 (0.65) | ALOX15LTA4HTOP2A | |
| SCHEMBL31303707 | 0.81 | ALOX15 (0.59) | ALOX15NPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL2817780 | 0.81 | ALOX15 (0.59) | ALOX15NPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL2815973 | 0.81 | ALOX15 (0.64) | ALOX15LTA4HTOP2A | |
| SCHEMBL2817894 | 0.81 | ALOX15 (0.64) | ALOX15LTA4HTOP2A | |
| SCHEMBL2817144 | 0.81 | ALOX15 (0.64) | ALOX15LTA4HTOP2A | |
| SCHEMBL2815571 | 0.81 | ALOX15 (0.64) | ALOX15LTA4HTOP2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011089576-A2 | NOVEL COMPOSITIONS FOR REDUCING Aß 42 PRODUCTION AND THEIR USE IN TREATING ALZHEIMER'S DISEASE (AD) | KAREUS THERAPEUTTICS SA (CH) | 2011-07-28 | — | — | WO | disclosed |