Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 3/20 | 0.35 |
| ▸ | KLK7 | P49862 | 6/20 | 0.35 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.33 |
| ▸ | DUT | P33316 | 1/20 | 0.33 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.33 |
| ▸ | KLK5 | Q9Y337 | 5/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | ELANE | P08246 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.32 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.32 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.32 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.32 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6868570 | 0.82 | HTT (0.39) | GPR119HPGDKMT2A | |
| SCHEMBL960356 | 0.78 | TOP2A (0.34) | TOP2AKLK7FKBP1ADUTGPR119 | |
| SCHEMBL2504329 | 0.78 | TOP2A (0.34) | TOP2AKLK7FKBP1ADUTGPR119 | |
| SCHEMBL190828 | 0.78 | TOP2A (0.34) | TOP2AKLK7FKBP1ADUTGPR119 | |
| SCHEMBL6861270 | 0.77 | PRMT5 (0.43) | KLK7 | |
| SCHEMBL8222384 | 0.77 | PRMT5 (0.43) | KLK7 | |
| SCHEMBL8119034 | 0.74 | RORC (0.37) | TOP2AGPR119KMT2A | |
| SCHEMBL352414 | 0.74 | CHRM2 (0.34) | TOP2AKLK7FKBP1ADUTGPR119 | |
| SCHEMBL16689223 | 0.73 | CHRM2 (0.35) | TOP2AFKBP1ADUTKMT2ASMN1; SMN2 | |
| SCHEMBL10025390 | 0.73 | CHRM2 (0.35) | TOP2AFKBP1ADUTKMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1004578-B1 | 5-oxo-pyrrolidine-2-carboxylic acid hydroxamide derivatives | PFIZER PROD INC (US) | 2004-02-25 | — | — | EP | disclosed |
| US-6114361-A | INHIBITORS OF MATRIX METALLOPROTEINASES AND REPROLYSIN; ADMINISTERING TO TREAT CONDITIONS WHICH CAN BE TREATED BY THE INHIBITION OF THESE ENZYMES | PFIZER INC. (US) | 2000-09-05 | — | — | US | disclosed |
| EP-1004578-A2 | 5-oxo-pyrrolidine-2-carboxylic acid hydroxamide derivatives | Pfizer Products Inc. (US) | 2000-05-31 | — | — | EP | disclosed |