SCHEMBL6861475

SCHEMBL6861475

O=C(Nc1ccn([C@@H]2O[C@]3(CO)CO[C@@H]2[C@@H]3O)c(=O)n1)c1ccccc1

nearest known ligand 0.58

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
ABL1 P00519 1/20 0.56
RIN1 Q13671 1/20 0.56
P2RY6 Q15077 2/20 0.51
P2RY14 Q15391 2/20 0.51
POLB P06746 1/20 0.51
NT5E P21589 1/20 0.51
MEN1 O00255 2/20 0.39
KMT2A Q03164 2/20 0.39
ADORA3 P0DMS8 1/20 0.39
NPC1 O15118 3/20 0.36
RAB9A P51151 3/20 0.36
P2RY12 Q9H244 1/20 0.36
HTR1A P08908 1/20 0.36
HTR1D P28221 1/20 0.36
HTR1B P28222 1/20 0.36
HTR1F P30939 1/20 0.36
LMNA P02545 1/20 0.35
SMN1; SMN2 Q16637 1/20 0.35
ST6GAL1 P15907 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12345959 0.93 ABL1 (0.52) ABL1RIN1P2RY6P2RY14POLB
SCHEMBL13722092 0.91 ABL1 (0.52) ABL1RIN1P2RY6P2RY14POLB
SCHEMBL4773710 0.90 ABL1 (0.54) ABL1RIN1P2RY6P2RY14POLB
SCHEMBL12408886 0.90 ABL1 (0.51) ABL1RIN1P2RY6P2RY14POLB
SCHEMBL10072470 0.90 ABL1 (0.51) ABL1RIN1P2RY6P2RY14POLB
SCHEMBL25629925 0.89 ABL1 (0.52) ABL1RIN1P2RY6P2RY14POLB
SCHEMBL14929222 0.84 ABL1 (0.42) ABL1RIN1P2RY6P2RY14POLB
SCHEMBL6879553 0.84 ABL1 (0.58) ABL1RIN1P2RY6P2RY14POLB
SCHEMBL19814666 0.84 ABL1 (0.42) ABL1RIN1P2RY6P2RY14POLB
SCHEMBL1096454 0.84 ABL1 (0.42) ABL1RIN1P2RY6P2RY14POLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6794499-B2 BICYCLIC LOCKED NUCLEOSIDE ANALOGUES EXIQON A/S (DK) 2004-09-21 US disclosed
US-20030134808-A1 Oligonucleotide analogues WENGEL JESPER (DK) 2003-07-17 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030134808-A1 Oligonucleotide analogues TARBP1, DCLRE1B, ADAR ABL1 4643/4885RIN1 3842/4885P2RY6 2779/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.