Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.58 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.58 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | CA12 | O43570 | 1/20 | 0.50 |
| ▸ | CA9 | Q16790 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | C5AR1 | P21730 | 1/20 | 0.44 |
| ▸ | BRD1 | O95696 | 1/20 | 0.44 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.44 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.42 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.42 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.42 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7077936 | 0.81 | MAPT (0.67) | MAPTMCOLN3HTTNPSR1L3MBTL1 | |
| SCHEMBL2119843 | 0.80 | MAPT (0.47) | MAPTMCOLN3HTTNPSR1L3MBTL1 | |
| SCHEMBL6863864 | 0.80 | MEN1 (0.39) | MAPTHTTNPSR1L3MBTL1ALDH1A1 | |
| SCHEMBL6864499 | 0.78 | NR3C1 (0.57) | MAPTNPSR1ALDH1A1LMNA | |
| SCHEMBL2008337 | 0.75 | MAPT (1.00) | MAPTMCOLN3HTTNPSR1L3MBTL1 | |
| SCHEMBL2117926 | 0.75 | MAPT (0.50) | MAPTMCOLN3HTTNPSR1L3MBTL1 | |
| SCHEMBL2117920 | 0.75 | MAPT (0.50) | MAPTMCOLN3HTTNPSR1L3MBTL1 | |
| SCHEMBL18031174 | 0.75 | MAPT (0.82) | MAPTMCOLN3HTTNPSR1L3MBTL1 | |
| SCHEMBL6302212 | 0.75 | MAPT (0.82) | MAPTMCOLN3HTTNPSR1L3MBTL1 | |
| SCHEMBL2119973 | 0.73 | MAPT (0.47) | MAPTMCOLN3HTTNPSR1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0973730-B1 | CALCILYTIC COMPOUNDS | SMITHKLINE BEECHAM CORP (US) | 2004-06-16 | — | — | EP | disclosed |
| US-6294531-B1 | AMINOALKANOLS AS BLOOD COAGULANTS | SMITHKLINE BEECHAM CORPORATION | 2001-09-25 | — | — | US | disclosed |
| EP-0973730-A1 | CALCILYTIC COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2000-01-26 | — | — | EP | disclosed |
| WO-1998045255-A1 | CALCILYTIC COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 1998-10-15 | — | — | WO | disclosed |