SCHEMBL6862043

SCHEMBL6862043

CCCCCC(Cl)=Cc1ccccc1

nearest known ligand 0.60

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 1/20 0.60
TDP1 Q9NUW8 1/20 0.58
CES2 O00748 2/20 0.43
CES1 P23141 2/20 0.43
KDM1A O60341 1/20 0.40
MEN1 O00255 2/20 0.40
KMT2A Q03164 2/20 0.40
EGFR P00533 1/20 0.40
EPHX2 P34913 1/20 0.39
TUBB4A P04350 2/20 0.39
TUBB P07437 2/20 0.39
TUBA3C P0DPH7 2/20 0.39
TUBA1B P68363 2/20 0.39
TUBA4A P68366 2/20 0.39
TUBB4B P68371 2/20 0.39
TUBB3 Q13509 2/20 0.39
TUBB2A Q13885 2/20 0.39
TUBB8 Q3ZCM7 2/20 0.39
TUBA3E Q6PEY2 2/20 0.39
TUBA1A Q71U36 2/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9452454 0.94 LMNA (0.53) LMNATDP1CES2CES1KDM1A
SCHEMBL9310728 0.86 LMNA (0.47) LMNATDP1CES2CES1KDM1A
SCHEMBL30439628 0.81 LMNA (0.64) LMNATDP1CES2CES1MEN1
SCHEMBL30444208 0.80 MAPT (0.50) CES1
SCHEMBL31718808 0.79 TDP1 (0.65) LMNATDP1CES2CES1MEN1
SCHEMBL8741682 0.79 LMNA (0.62) LMNATDP1CES2CES1MEN1
SCHEMBL2773836 0.79 LMNA (0.62) LMNATDP1CES2CES1MEN1
SCHEMBL10500965 0.79 TDP1 (0.65) LMNATDP1CES2CES1MEN1
SCHEMBL30225789 0.79 TDP1 (0.65) LMNATDP1CES2CES1MEN1
SCHEMBL28702570 0.79 TDP1 (0.65) LMNATDP1CES2CES1MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6710094-B2 MOLDED FOAM ARTICLES PREPARED USING THE FIRE-RETARDANT EXPANDABLE VINYL AROMATIC BEADS OF THIS INVENTION ARE RESISTANT TO FLAME, EVEN WHEN RELATIVELY LOW LEVELS OF THE FLAME RETARDANT STYROCHEM DELAWARE, INC. 2004-03-23 US disclosed
US-20030141031-A1 Processes for preparing patterns for use in metal castings NEW WINCUP HOLDINGS, INC. 2003-07-31 US disclosed
US-20020081379-A1 Treatment for the reduction of carbon defects in the lost foam process STYROCHEM DELAWARE, INC. 2002-06-27 US disclosed
US-20020028292-A1 Treatment for the reduction of carbon defects in the lost foam process STYROCHEM DELAWARE, INC. 2002-03-07 US disclosed
US-6303664-B1 PREPARING PATTERN FOR USE IN METAL CASTINGS BY ADDING HEXABROMOCYCLODODECANE OR TETRABROMOCYCLOOCTANE FLAME RETARDANTS TO VINYL AROMATIC MONOMER; SUSPENDING WATER; ADDING BLOWING AGENT; SEPARATING IMPREGNATED BEADS, WASHING, DRYING STYROCHEM DELAWARE, INC. 2001-10-16 US disclosed