Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 7/20 | 0.63 |
| ▸ | NPC1 | O15118 | 5/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.63 |
| ▸ | PIM1 | P11309 | 1/20 | 0.62 |
| ▸ | MAPT | P10636 | 2/20 | 0.62 |
| ▸ | LMNA | P02545 | 2/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.62 |
| ▸ | POLB | P06746 | 3/20 | 0.54 |
| ▸ | MAOA | P21397 | 1/20 | 0.49 |
| ▸ | BCAT1 | P54687 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.47 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.47 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.47 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.47 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.47 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.47 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | CA12 | O43570 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1297716 | 0.79 | PIM1 (0.72) | RAB9ANPC1ALDH1A1PIM1MAPT | |
| SCHEMBL602377 | 0.77 | RAB9A (0.78) | RAB9ANPC1ALDH1A1PIM1MAPT | |
| SCHEMBL2705460 | 0.77 | PIM1 (0.74) | RAB9ANPC1ALDH1A1PIM1MAPT | |
| SCHEMBL29523120 | 0.77 | PIM1 (1.00) | RAB9ANPC1ALDH1A1PIM1MAPT | |
| SCHEMBL2198563 | 0.77 | PIM1 (1.00) | RAB9ANPC1ALDH1A1PIM1MAPT | |
| SCHEMBL6299316 | 0.76 | PIM1 (0.68) | RAB9ANPC1ALDH1A1PIM1MAPT | |
| Hydrochloric Acid SCHEMBL10423094 | 0.76 | PIM1 (0.96) | RAB9ANPC1ALDH1A1PIM1MAPT | |
| SCHEMBL3619989 | 0.76 | PIM1 (0.72) | RAB9ANPC1ALDH1A1PIM1MAPT | |
| SCHEMBL18889274 | 0.75 | RAB9A (1.00) | RAB9ANPC1ALDH1A1PIM1MAPT | |
| SCHEMBL1066370 | 0.75 | PIM1 (0.66) | RAB9ANPC1ALDH1A1PIM1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1194426-B1 | BENZOFURANE DERIVATIVES | MERCK PATENT GMBH (DE) | 2004-08-18 | — | — | EP | claimed |
| US-6531503-B1 | Central nervous system | MERCK PATENT GMBH (DE) | 2003-03-11 | — | — | US | claimed |
| EP-1194426-A2 | BENZOFURANE DERIVATIVES | MERCK PATENT GmbH (DE) | 2002-04-10 | — | — | EP | claimed |
| WO-2001004112-A2 | BENZOFURANE DERIVATIVES | MERCK PATENT GMBH (DE) | 2001-01-18 | — | — | WO | claimed |
| EP-1194426-B1 | BENZOFURANE DERIVATIVES | MERCK PATENT GMBH (DE) | 2004-08-18 | — | — | EP | disclosed |
| US-6531503-B1 | Central nervous system | MERCK PATENT GMBH (DE) | 2003-03-11 | — | — | US | disclosed |
| EP-1194426-A2 | BENZOFURANE DERIVATIVES | MERCK PATENT GmbH (DE) | 2002-04-10 | — | — | EP | disclosed |
| WO-2001004112-A2 | BENZOFURANE DERIVATIVES | MERCK PATENT GMBH (DE) | 2001-01-18 | — | — | WO | disclosed |