Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | MAOB | P27338 | 8/20 | 0.42 |
| ▸ | RAB9A | P51151 | 4/20 | 0.40 |
| ▸ | NPC1 | O15118 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | MAOA | P21397 | 4/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | NOS2 | P35228 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | FAAH | O00519 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL779077 | 0.84 | ALDH1A1 (0.51) | MAPK1ALDH1A1MAOBRAB9ANPC1 | |
| SCHEMBL15597020 | 0.82 | MAPK1 (0.49) | MAPK1ALDH1A1MAOBRAB9ANPC1 | |
| SCHEMBL11990102 | 0.81 | MAPK1 (0.48) | MAPK1ALDH1A1MAOBRAB9ANPC1 | |
| SCHEMBL11989287 | 0.81 | ALDH1A1 (0.48) | MAPK1ALDH1A1MAOBRAB9ANPC1 | |
| SCHEMBL13803829 | 0.81 | ALDH1A1 (0.51) | MAPK1ALDH1A1MAOBRAB9ANPC1 | |
| SCHEMBL14743537 | 0.78 | ALDH1A1 (0.69) | MAPK1ALDH1A1MAOBRAB9ANPC1 | |
| SCHEMBL6165864 | 0.77 | ALDH1A1 (0.78) | MAPK1ALDH1A1MAOBRAB9ANPC1 | |
| SCHEMBL13604916 | 0.76 | ALDH1A1 (0.43) | MAPK1ALDH1A1MAOBRAB9ANPC1 | |
| SCHEMBL14919976 | 0.73 | MAPK1 (0.49) | MAPK1ALDH1A1MAOBRAB9ANPC1 | |
| SCHEMBL14959582 | 0.72 | APP (0.40) | ALDH1A1KMT2ALMNAMEN1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014028334-A1 | SELECTIVE MMP INHIBITORS | SYMPHONY EVOLUTION, INC. (US) | 2014-02-20 | — | — | WO | disclosed |
| WO-2011041545-A1 | METHODS OF TREATING ANEURYSMAL DILATATION, BLOOD VESSEL WALL WEAKNESS AND SPECIFICALLY ABDOMINAL AORTIC AND THORACIC ANEURYSM USING MATRIX METALLOPROTEASE-2 INHIBITORS | SYMPHONY EVOLUTION, INC. (US) | 2011-04-07 | — | — | WO | disclosed |