Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 7/20 | 0.64 |
| ▸ | F12 | P00748 | 8/20 | 0.45 |
| ▸ | F2 | P00734 | 6/20 | 0.45 |
| ▸ | PLAU | P00749 | 2/20 | 0.43 |
| ▸ | PLG | P00747 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.40 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6870656 | 0.93 | ADORA2A (0.59) | ADORA2AF12F2ATMALDH1A1 | |
| SCHEMBL6863726 | 0.93 | ADORA2A (0.56) | ADORA2AF12F2ALDH1A1LMNA | |
| SCHEMBL6867223 | 0.93 | ADORA2A (0.60) | ADORA2AF12F2PLAUPLG | |
| SCHEMBL6870369 | 0.91 | ADORA2A (0.61) | ADORA2AF12F2PLAUPLG | |
| SCHEMBL6866841 | 0.91 | ADORA2A (0.55) | ADORA2AF12F2ATMALDH1A1 | |
| SCHEMBL6869794 | 0.89 | ADORA2A (0.59) | ADORA2AF12F2PLAUPLG | |
| SCHEMBL6869823 | 0.89 | ADORA2A (0.56) | ADORA2AF12F2PLAUPLG | |
| SCHEMBL6870680 | 0.88 | ADORA2A (0.60) | ADORA2AF12F2PLAUALDH1A1 | |
| SCHEMBL6868956 | 0.87 | ADORA2A (0.59) | ADORA2AF12F2PLAUPLG | |
| SCHEMBL6871898 | 0.87 | ADORA2A (0.62) | ADORA2AF12F2PLAUPLG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1347974-B1 | AMINOTRIAZOLOPYRIDIINE DERIVATIVES AS ADENOSINE RECEPTOR LIGANDS | HOFFMANN LA ROCHE (CH) | 2004-11-03 | — | — | EP | disclosed |