Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 7/20 | 0.59 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | F12 | P00748 | 3/20 | 0.41 |
| ▸ | F2 | P00734 | 2/20 | 0.40 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.40 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6869823 | 0.94 | ADORA2A (0.56) | ADORA2AHPGDALDH1A1GAAF12 | |
| SCHEMBL6863310 | 0.93 | ADORA2A (0.64) | ADORA2AHPGDALDH1A1F12F2 | |
| SCHEMBL6873020 | 0.91 | ADORA2A (0.53) | ADORA2AGAAF12F2KDM4E | |
| SCHEMBL6867223 | 0.90 | ADORA2A (0.60) | ADORA2AF12F2 | |
| SCHEMBL6863726 | 0.86 | ADORA2A (0.56) | ADORA2AHPGDALDH1A1GAAF12 | |
| SCHEMBL6871898 | 0.85 | ADORA2A (0.62) | ADORA2AF12F2 | |
| SCHEMBL6870369 | 0.85 | ADORA2A (0.61) | ADORA2AF12F2 | |
| SCHEMBL6866841 | 0.85 | ADORA2A (0.55) | ADORA2AHPGDALDH1A1F12F2 | |
| SCHEMBL6869475 | 0.83 | ADORA2A (0.55) | ADORA2AF12F2HCRTR1HCRTR2 | |
| SCHEMBL6869794 | 0.83 | ADORA2A (0.59) | ADORA2AF12F2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1347974-B1 | AMINOTRIAZOLOPYRIDIINE DERIVATIVES AS ADENOSINE RECEPTOR LIGANDS | HOFFMANN LA ROCHE (CH) | 2004-11-03 | — | — | EP | disclosed |