Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 19/20 | 0.59 |
| ▸ | CHRNA4 | P43681 | 19/20 | 0.59 |
| ▸ | CHRNA3 | P32297 | 18/20 | 0.59 |
| ▸ | CHRNB3 | Q05901 | 17/20 | 0.59 |
| ▸ | CHRNA6 | Q15825 | 17/20 | 0.59 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30767290 | 0.78 | CHRNB2 (0.57) | CHRNB2CHRNA4CHRNA3CHRNB3CHRNA6 | |
| SCHEMBL25409415 | 0.78 | NR1H2 (0.56) | CHRNB2CHRNA4CHRNA3CHRNB3CHRNA6 | |
| SCHEMBL1979623 | 0.78 | NR1H2 (0.56) | CHRNB2CHRNA4CHRNA3CHRNB3CHRNA6 | |
| SCHEMBL1979172 | 0.78 | CHRNB2 (0.58) | CHRNB2CHRNA4CHRNA3CHRNB3CHRNA6 | |
| SCHEMBL994561 | 0.78 | NR1H2 (0.56) | CHRNB2CHRNA4CHRNA3CHRNB3CHRNA6 | |
| SCHEMBL1711284 | 0.77 | CHRNB2 (0.67) | CHRNB2CHRNA4CHRNA3CHRNB4 | |
| SCHEMBL1979000 | 0.77 | CHRNB2 (0.49) | CHRNB2CHRNA4CHRNA3CHRNB3CHRNA6 | |
| SCHEMBL1711502 | 0.77 | CHRNB2 (0.67) | CHRNB2CHRNA4CHRNA3CHRNB4 | |
| SCHEMBL1978998 | 0.77 | CHRNB2 (0.53) | CHRNB2CHRNA4CHRNA3CHRNB3CHRNA6 | |
| SCHEMBL1711262 | 0.77 | CHRNB2 (0.67) | CHRNB2CHRNA4CHRNA3CHRNB4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011071758-A1 | 3,6-DIAZABICYCLO[3.1.1]HEPTANES AS NEURONAL NICOTINIC ACETYLCHOLINE RECEPTOR LIGANDS | TARGACEPT, INC. (US) | 2011-06-16 | — | — | WO | disclosed |