Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 7/20 | 0.57 |
| ▸ | CHRNA4 | P43681 | 7/20 | 0.57 |
| ▸ | CHRNA3 | P32297 | 6/20 | 0.57 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.57 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | CHRNB3 | Q05901 | 5/20 | 0.34 |
| ▸ | CHRNA6 | Q15825 | 5/20 | 0.34 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.34 |
| ▸ | SCARB1 | Q8WTV0 | 1/20 | 0.33 |
| ▸ | PDE4A | P27815 | 1/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.33 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16472382 | 0.79 | CHRNB2 (0.57) | CHRNB2CHRNA4CHRNA3CHRNB4TSHR | |
| SCHEMBL12683426 | 0.79 | CHRNB2 (0.57) | CHRNB2CHRNA4CHRNA3CHRNB4TSHR | |
| SCHEMBL10005081 | 0.79 | — | — | |
| SCHEMBL11538376 | 0.79 | GAA (0.44) | TSHRSCARB1L3MBTL1 | |
| SCHEMBL11538373 | 0.79 | GAA (0.44) | TSHRSCARB1L3MBTL1 | |
| SCHEMBL6863487 | 0.78 | CHRNB2 (0.59) | CHRNB2CHRNA4CHRNA3CHRNB4CHRNB3 | |
| SCHEMBL15360065 | 0.78 | CHRNB2 (0.47) | CHRNB2CHRNA4CHRNA3CHRNB4TSHR | |
| SCHEMBL1005536 | 0.78 | NR1H2 (0.56) | USP2NR1H2 | |
| SCHEMBL64564 | 0.78 | NR1H2 (0.56) | USP2NR1H2 | |
| SCHEMBL4332763 | 0.78 | CHRNB2 (0.47) | CHRNB2CHRNA4CHRNA3CHRNB4TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12441731-B2 | Pyrazolopyrimidine compounds and uses thereof | INCYTE CORPORATION (US) | 2025-10-14 | — | — | US | disclosed |
| EP-3856348-B1 | PYRAZOLO[4,3-D]PYRIMIDINE COMPOUNDS AS ALK2 AND/OR FGFR MODULATORS | INCYTE CORP (US) | 2024-01-03 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12441731-B2 | Pyrazolopyrimidine compounds and uses thereof | ALK, FGFR1, FGFR2 | CHRNB2 3545/4885CHRNA4 4464/4885CHRNA3 4378/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.