Known targets — ChEMBL curated mechanism
CACNA1CCACNA1DCACNA1FCACNA1SDRD2HTR1BHTR1DHTR1F
The experimentally established mechanism targets of Malic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.88 |
| ▸ | TET2 | Q6N021 | 6/20 | 0.56 |
| ▸ | TET3 | O43151 | 2/20 | 0.56 |
| ▸ | TET1 | Q8NFU7 | 1/20 | 0.56 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.50 |
| ▸ | KDM4A | O75164 | 2/20 | 0.48 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.48 |
| ▸ | KDM2A | Q9Y2K7 | 2/20 | 0.48 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | GABRR1 | P24046 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | KMO | O15229 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Malic Acid SCHEMBL30036864 | 0.94 | — | — | |
| Malic Acid SCHEMBL28355917 | 0.94 | SMN1; SMN2 (1.00) | SMN1; SMN2TET2TET3TET1SLC22A6 | |
| Malic Acid SCHEMBL98496 | 0.94 | — | — | |
| Malic Acid SCHEMBL89131 | 0.94 | SMN1; SMN2 (1.00) | SMN1; SMN2TET2TET3TET1SLC22A6 | |
| Malic Acid SCHEMBL256122 | 0.94 | — | — | |
| Malic Acid SCHEMBL31673494 | 0.94 | — | — | |
| Malic Acid SCHEMBL31673489 | 0.94 | — | — | |
| Malic Acid SCHEMBL856 | 0.94 | — | — | |
| Malic Acid SCHEMBL14125844 | 0.94 | SMN1; SMN2 (1.00) | SMN1; SMN2TET2TET3TET1SLC22A6 | |
| Malic Acid SCHEMBL30036315 | 0.94 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113979667-B | Cement-based permeable crystallization composite active powder master batch for tunnel construction and preparation method thereof | 中铁隧道局集团有限公司 | 2022-08-05 | — | — | CN | claimed |
| CN-113979667-A | Cement-based permeable crystallization composite active powder master batch for tunnel construction and preparation method thereof | 中铁隧道局集团有限公司 | 2022-01-28 | — | — | CN | claimed |
| US-6800218-B2 | Abrasive free formulations for chemical mechanical polishing of copper and associated materials and method of using same | ADVANCED TECHNOLOGY MATERIALS, INC. | 2004-10-05 | — | — | US | claimed |
| US-4026711-A | TETRAKIS(HYDROXYMETHYL)PHOSPHONIUM PHOSPHATE-CARBOXYLATE, UREA | AMERICAN CYANAMID COMPANY (US) | 1977-05-31 | — | — | US | claimed |
| CN-113979667-B | Cement-based permeable crystallization composite active powder master batch for tunnel construction and preparation method thereof | 中铁隧道局集团有限公司 | 2022-08-05 | — | — | CN | disclosed |
| CN-113979667-B | Cement-based permeable crystallization composite active powder master batch for tunnel construction and preparation method thereof | 中铁隧道局集团有限公司 | 2022-08-05 | — | — | CN | disclosed |
| CN-114711351-A | A plant beverage for preventing and controlling diabetes | 天楠(福建)生物科技有限公司 | 2022-07-08 | — | — | CN | disclosed |
| CN-113979667-A | Cement-based permeable crystallization composite active powder master batch for tunnel construction and preparation method thereof | 中铁隧道局集团有限公司 | 2022-01-28 | — | — | CN | disclosed |
| CN-113979667-A | Cement-based permeable crystallization composite active powder master batch for tunnel construction and preparation method thereof | 中铁隧道局集团有限公司 | 2022-01-28 | — | — | CN | disclosed |
| US-4139614-A | FOR HUMAN AND VETERINARY MEDICINE | ROHM AND HAAS COMPANY (US) | 1979-02-13 | — | — | US | disclosed |