SCHEMBL6863776

SCHEMBL6863776

Fc1ccc(C(F)(F)F)c(-c2c(Cl)nc3ncnn3c2NC2CC3CCC2C3)c1

nearest known ligand 0.37

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
GABBR2 O75899 10/20 0.37
GABBR1 Q9UBS5 10/20 0.37
KDR P35968 1/20 0.37
AURKB Q96GD4 1/20 0.37
CNR2 P34972 3/20 0.36
MBOAT4 Q96T53 1/20 0.34
KDM4E B2RXH2 1/20 0.33
ALDH1A1 P00352 1/20 0.33
CNR1 P21554 2/20 0.33
PDE3B Q13370 1/20 0.33
PDE3A Q14432 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4817636 0.82 GABBR2 (0.39) GABBR2GABBR1KDRAURKB
SCHEMBL4821434 0.81 CNR1 (0.43) GABBR2GABBR1CNR2KDM4EALDH1A1
SCHEMBL7495679 0.80 GABBR2 (0.39) GABBR2GABBR1KDM4E
SCHEMBL7962438 0.79 GABBR2 (0.37) GABBR2GABBR1CNR2CNR1
SCHEMBL4821115 0.78 GABBR2 (0.34) GABBR2GABBR1CNR2ALDH1A1CNR1
SCHEMBL6186174 0.77 PDGFRB (0.38) GABBR2GABBR1KDRAURKB
SCHEMBL4819294 0.75 ALDH1A1 (0.43) GABBR2GABBR1KDM4EALDH1A1
SCHEMBL6410703 0.74 PDGFRB (0.36) GABBR2GABBR1
SCHEMBL6995496 0.66 MAPK1 (0.39) MBOAT4KDM4EALDH1A1
SCHEMBL4820252 0.64 MAPK1 (0.40) MBOAT4KDM4EALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1341794-B1 FUNGICIDAL 6-(TRIFLUOROMETHYL-PHENYL)-TRIAZOLOPYRIMIDINES BASF AG (DE) 2004-08-18 EP claimed