SCHEMBL6864491

SCHEMBL6864491

CCC=Cc1cccc([SiH3])c1

nearest known ligand 0.38

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
NFE2L2 Q16236 1/20 0.34
CHRM2 P08172 1/20 0.34
CHRM1 P11229 1/20 0.34
CHRM3 P20309 1/20 0.34
CYP4F2 P78329 1/20 0.33
CYP4A11 Q02928 1/20 0.33
KDM4E B2RXH2 1/20 0.33
ALDH1A1 P00352 1/20 0.33
SMN1; SMN2 Q16637 1/20 0.33
HTR2A P28223 3/20 0.32
SLC6A19 Q695T7 1/20 0.32
APP P05067 2/20 0.32
RELA Q04206 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31149192 0.85 NFE2L2 (0.41) NFE2L2CHRM2CHRM1CHRM3HTR2A
SCHEMBL8442071 0.78 TP53 (0.52) NFE2L2SMN1; SMN2RELA
SCHEMBL19227545 0.78 TP53 (0.52) NFE2L2SMN1; SMN2RELA
SCHEMBL8442069 0.78 TP53 (0.52) NFE2L2SMN1; SMN2RELA
SCHEMBL7545882 0.77 APP (0.40) CYP4F2CYP4A11APP
SCHEMBL256054 0.76 SLC6A19 (0.53) ALDH1A1SLC6A19
SCHEMBL14041341 0.76 CHRM2 (0.37) NFE2L2CHRM2CHRM1CHRM3CYP4F2
SCHEMBL14416285 0.76 SLC6A19 (0.53) ALDH1A1SLC6A19
SCHEMBL16167423 0.76 CYP19A1 (0.59) APP
SCHEMBL7790649 0.76 TP53 (0.50) NFE2L2CHRM2CHRM1CHRM3CYP4F2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-1204149-C Improved olefin polymerization process DOW CHEMICAL CO (US) 2005-06-01 CN disclosed
EP-1054910-B1 IMPROVED OLEFIN POLYMERIZATION PROCESS DOW GLOBAL TECHNOLOGIES INC (US) 2004-09-22 EP disclosed
US-6258902-B1 USING A METAL COMPLEX CATALYST AND AN ALKENYL CONTAINING HYDROCARBYLSILANE THE DOW CHEMICAL COMPANY 2001-07-10 US disclosed
CN-1289343-A Improved olefin polymerization process DOW CHEMICAL CO (US) 2001-03-28 CN disclosed