Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR52 | Q9Y2T5 | 14/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | PPARA | Q07869 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13505716 | 0.92 | SMN1; SMN2 (0.57) | GPR52ALDH1A1SMN1; SMN2NPC1MAPT | |
| SCHEMBL6864601 | 0.89 | GPR52 (0.53) | GPR52ALDH1A1SMN1; SMN2NPC1MAPT | |
| SCHEMBL13505788 | 0.88 | MAPT (0.51) | GPR52ALDH1A1SMN1; SMN2NPC1MAPT | |
| SCHEMBL6863606 | 0.86 | GPR52 (0.67) | GPR52ALDH1A1SMN1; SMN2PPARA | |
| SCHEMBL6863562 | 0.81 | GPR52 (0.56) | GPR52ALDH1A1SMN1; SMN2 | |
| SCHEMBL1849568 | 0.78 | GPR52 (0.73) | GPR52 | |
| SCHEMBL6864575 | 0.78 | GPR52 (0.52) | GPR52ALDH1A1SMN1; SMN2NPC1MAPT | |
| SCHEMBL6864272 | 0.75 | GPR52 (0.50) | GPR52 | |
| SCHEMBL1850960 | 0.74 | GPR52 (0.57) | GPR52 | |
| SCHEMBL13505468 | 0.73 | GPR52 (0.69) | GPR52ALDH1A1SMN1; SMN2NPC1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2518054-A1 | AMIDE COMPOUND | Takeda Pharmaceutical Company Limited (JP) | 2012-10-31 | — | — | EP | disclosed |
| WO-2011078360-A1 | AMIDE COMPOUND | 武田薬品工業株式会社 (JP) | 2011-06-30 | — | — | WO | disclosed |