Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ILK | Q13418 | 5/20 | 0.59 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | APP | P05067 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | ESR1 | P03372 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.37 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.37 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.37 |
| ▸ | NCF1 | P14598 | 1/20 | 0.36 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.36 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL687334 | 0.75 | ILK (0.77) | ILKCA2APPSMN1; SMN2HTT | |
| SCHEMBL17747833 | 0.74 | RAB9A (0.61) | ILKCA2SMN1; SMN2MAPTNPC1 | |
| SCHEMBL17859472 | 0.74 | ILK (0.61) | ILKCA2SMN1; SMN2HTTKDM4E | |
| SCHEMBL3468695 | 0.67 | HRH3 (0.56) | ILKSMN1; SMN2HTTHPGDHRH3 | |
| SCHEMBL21256934 | 0.65 | MAPT (0.53) | ILKAPPSMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL677874 | 0.65 | ILK (0.76) | ILKHRH3 | |
| SCHEMBL3468573 | 0.65 | HRH3 (0.82) | ILKSMN1; SMN2HTTKDM4EALDH1A1 | |
| SCHEMBL31428715 | 0.65 | HRH3 (0.49) | ILKCA2SMN1; SMN2HTTHRH3 | |
| SCHEMBL34471642 | 0.65 | HRH3 (0.49) | ILKCA2SMN1; SMN2HTTKDM4E | |
| SCHEMBL686551 | 0.64 | ILK (0.76) | ILK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1542997-B1 | PYRAZOLYLBENZOTHIAZOLE DERIVATIVES AND THEIR USE AS THERAPEUTIC AGENTS | DERMIRA CANADA INC (CA) | 2012-02-29 | — | — | EP | disclosed |