Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR2 | P25025 | 17/20 | 0.54 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.49 |
| ▸ | CX3CR1 | P49238 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4375736 | 0.91 | ALDH1A1 (0.53) | HPGDLMNATSHRMAPK1 | |
| SCHEMBL4379759 | 0.89 | CXCR2 (0.42) | CXCR2CHRM5CX3CR1HPGDLMNA | |
| SCHEMBL4373934 | 0.81 | HPGD (0.69) | CXCR2HPGDLMNATSHRMAPK1 | |
| SCHEMBL4845916 | 0.81 | CXCR2 (0.39) | CXCR2CHRM5CX3CR1 | |
| SCHEMBL3583064 | 0.78 | MAPT (0.64) | HPGDLMNA | |
| SCHEMBL4381940 | 0.78 | HPGD (0.49) | HPGDLMNATSHR | |
| SCHEMBL3456632 | 0.78 | CXCR2 (0.44) | CXCR2CHRM5CX3CR1 | |
| SCHEMBL3536004 | 0.77 | MAPT (0.65) | HPGDLMNA | |
| SCHEMBL6865116 | 0.74 | CXCR2 (0.53) | CXCR2CHRM5CX3CR1 | |
| SCHEMBL6997947 | 0.74 | CXCR2 (0.56) | CXCR2CHRM5CX3CR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1686119-B1 | Pyrimidine-5-one derivatives as LDL-PLA2 inhibitors | SMITHKLINE BEECHAM PLC (GB) | 2009-07-29 | — | — | EP | disclosed |
| EP-1686119-A1 | PYRIMIDINE-4-ONE DERIVATIVES AS LDL-PLA2 INHIBITORS | SMITHKLINE BEECHAM PLC (GB) | 2006-08-02 | — | — | EP | disclosed |
| EP-1263740-B1 | PYRIMIDINE-4-ONE DERIVATIVE AS LDL-PLA2 INHIBITOR | SMITHKLINE BEECHAM PLC (GB) | 2006-07-19 | — | — | EP | disclosed |