Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | COPS5 | Q92905 | 1/20 | 0.45 |
| ▸ | IDO1 | P14902 | 1/20 | 0.45 |
| ▸ | CA5A | P35218 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | EGFR | P00533 | 1/20 | 0.43 |
| ▸ | MET | P08581 | 1/20 | 0.43 |
| ▸ | CXCR2 | P25025 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6866758 | 0.86 | MEN1 (0.57) | HPGDSMN1; SMN2TSHRMAPTMEN1 | |
| SCHEMBL6866806 | 0.86 | CTSB (0.38) | HPGDSMN1; SMN2HTTTSHRMAPT | |
| SCHEMBL6864187 | 0.82 | KMT2A (0.60) | TSHRMEN1KMT2ACXCR2LMNA | |
| SCHEMBL6865630 | 0.82 | CXCR2 (0.47) | HPGDSMN1; SMN2TSHRMAPTMEN1 | |
| SCHEMBL6866177 | 0.81 | CXCR2 (0.46) | SMN1; SMN2HTTMAPTMEN1KMT2A | |
| SCHEMBL841338 | 0.76 | CXCR2 (0.66) | SMN1; SMN2HTTTSHRMAPTCXCR2 | |
| SCHEMBL4227284 | 0.76 | MAPT (0.45) | HPGDSMN1; SMN2HTTTSHRMAPT | |
| SCHEMBL6868931 | 0.75 | CXCR2 (0.47) | MEN1KMT2ACXCR2LMNA | |
| SCHEMBL6863908 | 0.74 | CXCR2 (0.56) | HPGDKMT2ACXCR2 | |
| SCHEMBL6868838 | 0.74 | CTSB (0.52) | SMN1; SMN2MAPTMEN1KMT2ACXCR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6806273-B1 | 5-THIO-THIAZOLO(4,5-D)PYRIMIDIN-7-YL DERIVATIVES; CHEMOKINE RECEPTOR (ESPECIALLY CXCR2) ACTIVITY MODULATORS | ASTRAZENECA AB (SE) | 2004-10-19 | — | — | US | claimed |
| EP-1104425-B1 | NOVEL THIAZOLOPYRIMIDINE COMPOUNDS | ASTRAZENECA AB (SE) | 2003-01-29 | — | — | EP | claimed |
| US-6806273-B1 | 5-THIO-THIAZOLO(4,5-D)PYRIMIDIN-7-YL DERIVATIVES; CHEMOKINE RECEPTOR (ESPECIALLY CXCR2) ACTIVITY MODULATORS | ASTRAZENECA AB (SE) | 2004-10-19 | — | — | US | disclosed |
| EP-1104425-B1 | NOVEL THIAZOLOPYRIMIDINE COMPOUNDS | ASTRAZENECA AB (SE) | 2003-01-29 | — | — | EP | disclosed |