Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NLRP3 | Q96P20 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | CES2 | O00748 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.32 |
| ▸ | SCN7A | Q01118 | 1/20 | 0.31 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.31 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
| ▸ | TRIP13 | Q15645 | 1/20 | 0.30 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.30 |
| ▸ | ACP1 | P24666 | 1/20 | 0.30 |
| ▸ | CDC25B | P30305 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6865571 | 1.00 | NLRP3 (0.39) | NLRP3ALDH1A1LMNAHSD17B10CES2 | |
| SCHEMBL6865569 | 1.00 | NLRP3 (0.39) | NLRP3ALDH1A1LMNAHSD17B10CES2 | |
| SCHEMBL20691407 | 0.89 | NLRP3 (0.37) | NLRP3ALDH1A1LMNAHSD17B10CES2 | |
| SCHEMBL8022057 | 0.85 | AKR1C4 (0.39) | NLRP3ALDH1A1LMNAHSD17B10THRB | |
| SCHEMBL7717295 | 0.85 | AKR1C4 (0.39) | NLRP3ALDH1A1LMNAHSD17B10THRB | |
| SCHEMBL7719151 | 0.85 | AKR1C4 (0.39) | NLRP3ALDH1A1LMNAHSD17B10THRB | |
| SCHEMBL7717242 | 0.85 | AKR1C4 (0.39) | NLRP3ALDH1A1LMNAHSD17B10THRB | |
| SCHEMBL6857749 | 0.79 | NLRP3 (0.36) | NLRP3LMNATHRBSMN1; SMN2 | |
| SCHEMBL24483677 | 0.77 | NLRP3 (0.36) | NLRP3ALDH1A1LMNAHSD17B10 | |
| SCHEMBL6862150 | 0.75 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0999204-B1 | NOVEL COMPOUND HAVING EFFECT OF PROMOTING NEURON DIFFERENTIATION | NIPPON KAYAKU KK (JP) | 2004-10-13 | — | — | EP | disclosed |
| US-6384063-B1 | Compound having effect of promoting neuron differentiation | NIPPON KAYAKU KABUSHIKI KAISHA (JP) | 2002-05-07 | — | — | US | disclosed |
| EP-0999204-A1 | NOVEL COMPOUND HAVING EFFECT OF PROMOTING NEURON DIFFERENTIATION | Nippon Kayaku Kabushiki Kaisha (JP) | 2000-05-10 | — | — | EP | disclosed |