Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR2 | P25025 | 13/20 | 0.57 |
| ▸ | PAK4 | O96013 | 2/20 | 0.52 |
| ▸ | CXCR1 | P25024 | 1/20 | 0.47 |
| ▸ | CX3CR1 | P49238 | 11/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6863672 | 0.91 | PAK4 (0.62) | CXCR2PAK4CXCR1CX3CR1CYP1A2 | |
| SCHEMBL6868070 | 0.89 | CXCR2 (0.61) | CXCR2PAK4CXCR1CX3CR1CYP1A2 | |
| SCHEMBL6869141 | 0.88 | CXCR2 (0.57) | CXCR2PAK4CXCR1CX3CR1CYP1A2 | |
| SCHEMBL6866371 | 0.88 | CXCR2 (0.59) | CXCR2PAK4CXCR1CX3CR1 | |
| SCHEMBL6865622 | 0.87 | CXCR2 (0.58) | CXCR2PAK4CXCR1CX3CR1 | |
| SCHEMBL6991839 | 0.87 | PAK4 (0.57) | CXCR2PAK4CX3CR1CYP1A2MAPT | |
| SCHEMBL6869027 | 0.86 | CXCR2 (0.61) | CXCR2PAK4CXCR1CX3CR1 | |
| SCHEMBL6866384 | 0.85 | CXCR2 (0.56) | CXCR2PAK4CXCR1CX3CR1 | |
| SCHEMBL6864085 | 0.85 | CX3CR1 (0.55) | CXCR2PAK4CX3CR1 | |
| SCHEMBL6868967 | 0.85 | CXCR2 (0.69) | CXCR2CXCR1CX3CR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6806273-B1 | 5-THIO-THIAZOLO(4,5-D)PYRIMIDIN-7-YL DERIVATIVES; CHEMOKINE RECEPTOR (ESPECIALLY CXCR2) ACTIVITY MODULATORS | ASTRAZENECA AB (SE) | 2004-10-19 | — | — | US | claimed |
| EP-1104425-B1 | NOVEL THIAZOLOPYRIMIDINE COMPOUNDS | ASTRAZENECA AB (SE) | 2003-01-29 | — | — | EP | claimed |
| US-6806273-B1 | 5-THIO-THIAZOLO(4,5-D)PYRIMIDIN-7-YL DERIVATIVES; CHEMOKINE RECEPTOR (ESPECIALLY CXCR2) ACTIVITY MODULATORS | ASTRAZENECA AB (SE) | 2004-10-19 | — | — | US | disclosed |
| EP-1104425-B1 | NOVEL THIAZOLOPYRIMIDINE COMPOUNDS | ASTRAZENECA AB (SE) | 2003-01-29 | — | — | EP | disclosed |
| EP-1104425-A1 | NOVEL THIAZOLOPYRIMIDINE COMPOUNDS | AstraZeneca AB (SE) | 2001-06-06 | — | — | EP | disclosed |
| WO-2000009511-A1 | NOVEL THIAZOLOPYRIMIDINE COMPOUNDS | ASTRAZENECA AB (SE) | 2000-02-24 | — | — | WO | disclosed |