Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CX3CR1 | P49238 | 16/20 | 0.55 |
| ▸ | CXCR2 | P25025 | 15/20 | 0.55 |
| ▸ | PAK4 | O96013 | 2/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6866675 | 0.93 | CXCR2 (0.66) | CX3CR1CXCR2PAK4 | |
| SCHEMBL6866196 | 0.90 | CX3CR1 (0.69) | CX3CR1CXCR2 | |
| SCHEMBL6865593 | 0.89 | CXCR2 (0.67) | CX3CR1CXCR2PAK4 | |
| SCHEMBL6991839 | 0.89 | PAK4 (0.57) | CX3CR1CXCR2PAK4 | |
| SCHEMBL6865683 | 0.85 | CXCR2 (0.57) | CX3CR1CXCR2PAK4 | |
| SCHEMBL6865140 | 0.84 | PAK4 (0.56) | CX3CR1CXCR2PAK4 | |
| SCHEMBL6869005 | 0.82 | CXCR2 (0.72) | CX3CR1CXCR2PAK4 | |
| SCHEMBL6868639 | 0.82 | CXCR2 (0.66) | CX3CR1CXCR2 | |
| SCHEMBL6869357 | 0.80 | CX3CR1 (0.76) | CX3CR1CXCR2PAK4 | |
| SCHEMBL6863857 | 0.80 | CX3CR1 (0.69) | CX3CR1CXCR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6806273-B1 | 5-THIO-THIAZOLO(4,5-D)PYRIMIDIN-7-YL DERIVATIVES; CHEMOKINE RECEPTOR (ESPECIALLY CXCR2) ACTIVITY MODULATORS | ASTRAZENECA AB (SE) | 2004-10-19 | — | — | US | claimed |
| EP-1104425-B1 | NOVEL THIAZOLOPYRIMIDINE COMPOUNDS | ASTRAZENECA AB (SE) | 2003-01-29 | — | — | EP | claimed |
| US-6806273-B1 | 5-THIO-THIAZOLO(4,5-D)PYRIMIDIN-7-YL DERIVATIVES; CHEMOKINE RECEPTOR (ESPECIALLY CXCR2) ACTIVITY MODULATORS | ASTRAZENECA AB (SE) | 2004-10-19 | — | — | US | disclosed |
| EP-1104425-B1 | NOVEL THIAZOLOPYRIMIDINE COMPOUNDS | ASTRAZENECA AB (SE) | 2003-01-29 | — | — | EP | disclosed |