Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 16/20 | 0.52 |
| ▸ | PDE4D | Q08499 | 12/20 | 0.52 |
| ▸ | PDE4B | Q07343 | 12/20 | 0.52 |
| ▸ | PDE4C | Q08493 | 11/20 | 0.52 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6858739 | 0.88 | PDE4A (0.55) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL7353005 | 0.85 | PDE4D (0.48) | PDE4APDE4DPDE4BPDE4CALOX5AP | |
| SCHEMBL27521810 | 0.77 | PDE4A (0.60) | PDE4APDE4DPDE4BPDE4CPOLB | |
| SCHEMBL7355035 | 0.77 | PDE4A (0.51) | PDE4APDE4DPDE4BPDE4CPOLB | |
| SCHEMBL6864582 | 0.76 | PDE4D (0.58) | PDE4APDE4DPDE4BPDE4CPOLB | |
| SCHEMBL8482644 | 0.76 | PDE4A (0.60) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL6865413 | 0.75 | PDE4A (0.56) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL6862980 | 0.75 | PDE4B (0.66) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL7352735 | 0.74 | PDE4D (0.53) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL7441908 | 0.72 | PDE4B (0.54) | PDE4APDE4DPDE4BPDE4CPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0652868-B1 | INHIBITORS OF c-AMP PHOSPHODIESTERASE | AVENTIS PHARMA LTD (GB) | 2004-11-10 | — | — | EP | claimed |
| EP-0741707-B1 | SUBSTITUTED AROMATIC COMPOUNDS AS c.AMP PHOSPHODIESTERASE- AND TNF-INHIBITORS | RHONE POULENC RORER LTD (GB) | 1998-04-01 | — | — | EP | disclosed |
| EP-0741707-A1 | SUBSTITUTED AROMATIC COMPOUNDS AS c.AMP PHOSPHODIESTERASE- AND TNF-INHIBITORS | RHONE-POULENC RORER LIMITED (GB) | 1996-11-13 | — | — | EP | disclosed |
| WO-1995020578-A1 | SUBSTITUTED AROMATIC COMPOUNDS AS c.AMP PHOSPHODIESTERASE- AND TNF-INHIBITORS | RHONE-POULENC RORER LIMITED (GB) | 1995-08-03 | — | — | WO | disclosed |