Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 11/20 | 0.51 |
| ▸ | PDE4B | Q07343 | 11/20 | 0.50 |
| ▸ | PDE4C | Q08493 | 8/20 | 0.48 |
| ▸ | PDE4D | Q08499 | 8/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27521810 | 0.83 | PDE4A (0.60) | PDE4APDE4BPDE4CPDE4DCYP1A2 | |
| SCHEMBL15450963 | 0.81 | CA2 (0.59) | — | |
| SCHEMBL2889893 | 0.78 | PDE4A (0.58) | PDE4APDE4BPDE4CPDE4DCYP1A2 | |
| SCHEMBL6865694 | 0.77 | PDE4A (0.52) | PDE4APDE4BPDE4CPDE4DPOLB | |
| SCHEMBL3976102 | 0.76 | PDE4B (0.57) | PDE4APDE4BPDE4CPDE4DPOLB | |
| SCHEMBL5823060 | 0.75 | PDE4A (0.77) | PDE4APDE4BPDE4CPDE4DPOLB | |
| SCHEMBL6858739 | 0.75 | PDE4A (0.55) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL8337382 | 0.74 | CA12 (0.59) | — | |
| SCHEMBL8477546 | 0.74 | PDE4A (0.62) | PDE4APDE4BPDE4CPDE4DCYP1A2 | |
| SCHEMBL7333965 | 0.74 | PDE4B (0.56) | PDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4971959-A | Trisubstituted phenyl analogs having activity for congestive heart failure | WARNER-LAMBERT COMPANY (US) | 1990-11-20 | — | — | US | disclosed |