Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRD1 | P41143 | 19/20 | 0.83 |
| ▸ | OPRM1 | P35372 | 16/20 | 0.83 |
| ▸ | OPRK1 | P41145 | 13/20 | 0.83 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6394863 | 0.95 | OPRD1 (0.88) | OPRD1OPRM1OPRK1 | |
| SCHEMBL6870724 | 0.88 | OPRD1 (0.77) | OPRD1OPRM1OPRK1 | |
| SCHEMBL6395178 | 0.88 | OPRD1 (0.78) | OPRD1OPRM1OPRK1 | |
| SCHEMBL6327345 | 0.87 | OPRD1 (0.86) | OPRD1OPRM1OPRK1 | |
| SCHEMBL5491700 | 0.87 | OPRD1 (1.00) | OPRD1OPRM1OPRK1 | |
| SCHEMBL5495175 | 0.86 | OPRD1 (0.86) | OPRD1OPRM1OPRK1 | |
| SCHEMBL5485654 | 0.85 | OPRD1 (1.00) | OPRD1OPRM1OPRK1 | |
| SCHEMBL6393279 | 0.85 | OPRD1 (0.87) | OPRD1OPRM1OPRK1 | |
| SCHEMBL14492937 | 0.85 | OPRD1 (1.00) | OPRD1OPRM1OPRK1 | |
| SCHEMBL6176767 | 0.84 | OPRD1 (1.00) | OPRD1OPRM1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1428821-A1 | Piperidin-4-yl amines with analgesic effect | AstraZeneca AB (SE) | 2004-06-16 | — | — | EP | disclosed |
| EP-0946510-B1 | NOVEL COMPOUNDS WITH ANALGESIC EFFECT | ASTRAZENECA AB (SE) | 2004-05-12 | — | — | EP | disclosed |
| US-6399635-B1 | N,N-DIETHYL-4-(N-PIPERIDIN-3-YL-ANILINO) BENZAMIDE COMPOUND; REDUCTIVE AMINATION OF A 3-PIPERIDONE, ARYLATION | ASTRAZENECA CANADA INC. (CA) | 2002-06-04 | — | — | US | disclosed |
| US-6153626-A | Compounds with analgesic effect | ASTRA PHARMA INC. (CA) | 2000-11-28 | — | — | US | disclosed |