Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 10/20 | 0.66 |
| ▸ | CTRB1 | P17538 | 7/20 | 0.66 |
| ▸ | LCK | P06239 | 1/20 | 0.37 |
| ▸ | ACSS2 | Q9NR19 | 1/20 | 0.35 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.34 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6499069 | 0.84 | ELANE (0.68) | ELANECTRB1LCKP2RX7BRD9 | |
| SCHEMBL6638795 | 0.83 | ELANE (0.61) | ELANECTRB1LCKP2RX7NPC1 | |
| SCHEMBL7449565 | 0.81 | ELANE (0.58) | ELANECTRB1LCKP2RX7 | |
| SCHEMBL6641652 | 0.80 | CTRB1 (0.57) | ELANECTRB1LCKP2RX7NPC1 | |
| SCHEMBL6504148 | 0.80 | ELANE (1.00) | ELANECTRB1 | |
| SCHEMBL6496719 | 0.80 | ELANE (1.00) | ELANECTRB1 | |
| SCHEMBL6504081 | 0.79 | ELANE (0.67) | ELANECTRB1P2RX7 | |
| SCHEMBL6640343 | 0.79 | CTRB1 (0.55) | ELANECTRB1MEN1NPC1RAB9A | |
| SCHEMBL6495958 | 0.78 | ELANE (0.78) | ELANECTRB1LCK | |
| SCHEMBL6638831 | 0.78 | CTRB1 (0.54) | ELANECTRB1P2RX7GAARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6806269-B1 | EFFECTIVE AT LOWER CONCENTRATIONS; SUCH AS 6-(((1,1-DIMETHYL-ETHOXY)CARBONYL)AMINO)-5-METHYL-2-(METHYL(PHENYLMETHYL) -AMINO)-4H-3,1-BENZOXAZIN-4-ONE | G. D. SEARLE & COP | 2004-10-19 | — | — | US | claimed |