Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | XDH | P47989 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.51 |
| ▸ | GFER | P55789 | 1/20 | 0.51 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.51 |
| ▸ | RELA | Q04206 | 1/20 | 0.51 |
| ▸ | FUT7 | Q11130 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | PDE4A | P27815 | 2/20 | 0.46 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.46 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.46 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | CREBBP | Q92793 | 2/20 | 0.45 |
| ▸ | CA12 | O43570 | 2/20 | 0.45 |
| ▸ | CA1 | P00915 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6865895 | 0.90 | CREBBP (0.49) | LMNAXDHKDM4EPOLBGAA | |
| SCHEMBL16055159 | 0.88 | CA12 (0.53) | PDE4APDE4BPDE4CPDE4DCA12 | |
| SCHEMBL28343949 | 0.83 | LMNA (0.58) | LMNAXDHKDM4EPOLBGAA | |
| SCHEMBL2965222 | 0.83 | USP2 (0.49) | KDM4EGAATDP1PDE4APDE4B | |
| SCHEMBL6872463 | 0.83 | CREBBP (0.44) | LMNAXDHKDM4EPOLBGAA | |
| SCHEMBL23755951 | 0.82 | KDM4E (0.46) | LMNAXDHKDM4EPOLBGAA | |
| SCHEMBL16055084 | 0.81 | ESR1 (0.49) | LMNAXDHKDM4EPOLBGAA | |
| SCHEMBL9276266 | 0.81 | LMNA (0.51) | LMNAXDHKDM4EPOLBGAA | |
| SCHEMBL6872746 | 0.81 | LMNA (0.69) | LMNAXDHKDM4EPOLBGAA | |
| SCHEMBL6865198 | 0.80 | HPGD (0.71) | LMNAKDM4EL3MBTL1HPGDKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6821980-B1 | Substituted 5-benzyl-2,4-diaminopyrimidines | BASILEA PHARMACEUTICA AG (CH) | 2004-11-23 | — | — | US | disclosed |