Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.71 |
| ▸ | LMNA | P02545 | 2/20 | 0.71 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.50 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | EGFR | P00533 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | PPIA | P62937 | 1/20 | 0.46 |
| ▸ | SRC | P12931 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16447278 | 0.92 | HPGD (0.65) | HPGDLMNASMPD1HDAC1HDAC8 | |
| SCHEMBL30102539 | 0.88 | LMNA (0.76) | HPGDLMNASMPD1HDAC1HDAC8 | |
| SCHEMBL4874871 | 0.88 | LMNA (0.76) | HPGDLMNASMPD1HDAC1HDAC8 | |
| SCHEMBL16616383 | 0.87 | HPGD (0.53) | HPGDLMNASMN1; SMN2RAB9ANPC1 | |
| SCHEMBL6875862 | 0.87 | LMNA (0.59) | HPGDLMNASMPD1HDAC1HDAC8 | |
| SCHEMBL24983425 | 0.86 | HPGD (0.84) | HPGDLMNASMPD1HDAC1HDAC8 | |
| SCHEMBL30892445 | 0.86 | HPGD (0.84) | HPGDLMNASMPD1HDAC1HDAC8 | |
| SCHEMBL7045904 | 0.86 | MEN1 (0.56) | HPGDLMNASMN1; SMN2RAB9ANPC1 | |
| SCHEMBL21738207 | 0.85 | HPGD (0.77) | HPGDLMNASMPD1HDAC1HDAC8 | |
| SCHEMBL1919991 | 0.85 | LMNA (0.72) | HPGDLMNASMPD1HDAC1HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6821980-B1 | Substituted 5-benzyl-2,4-diaminopyrimidines | BASILEA PHARMACEUTICA AG (CH) | 2004-11-23 | — | — | US | disclosed |