Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.56 |
| ▸ | RAB9A | P51151 | 5/20 | 0.56 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.46 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.44 |
| ▸ | MEN1 | O00255 | 4/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 6/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | SYK | P43405 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6866756 | 1.00 | NPC1 (0.56) | NPC1RAB9ATAS1R3TAS1R1TP53 | |
| SCHEMBL6876167 | 0.93 | NPC1 (0.47) | NPC1RAB9ATP53KMT2AMEN1 | |
| SCHEMBL6876164 | 0.93 | NPC1 (0.47) | NPC1RAB9ATP53KMT2AMEN1 | |
| SCHEMBL6876610 | 0.91 | EPHX2 (0.46) | NPC1RAB9ATP53KMT2AMEN1 | |
| SCHEMBL6876601 | 0.91 | EPHX2 (0.46) | NPC1RAB9ATP53KMT2AMEN1 | |
| SCHEMBL6874872 | 0.90 | NPC1 (0.54) | NPC1RAB9ATP53KMT2AMEN1 | |
| SCHEMBL6874878 | 0.90 | NPC1 (0.54) | NPC1RAB9ATP53KMT2AMEN1 | |
| SCHEMBL6872661 | 0.89 | MEN1 (0.52) | NPC1RAB9ATP53KMT2AMEN1 | |
| SCHEMBL6872663 | 0.89 | MEN1 (0.52) | NPC1RAB9ATP53KMT2AMEN1 | |
| SCHEMBL6877480 | 0.89 | NOX1 (0.48) | NPC1RAB9AKMT2AMEN1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |