Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOX1 | Q9Y5S8 | 2/20 | 0.48 |
| ▸ | GBA1 | P04062 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 5/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.42 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.42 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.41 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.41 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | DHODH | Q02127 | 1/20 | 0.41 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.41 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.41 |
| ▸ | LTA4H | P09960 | 1/20 | 0.40 |
| ▸ | FAAH | O00519 | 1/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6877475 | 1.00 | NOX1 (0.48) | NOX1GBA1RAB9ANPC1MEN1 | |
| SCHEMBL6876429 | 0.90 | USP30 (0.43) | RAB9ANPC1KMT2AADRA2AMCHR1 | |
| SCHEMBL6876423 | 0.90 | USP30 (0.43) | RAB9ANPC1KMT2AADRA2AMCHR1 | |
| SCHEMBL6866751 | 0.89 | NPC1 (0.56) | RAB9ANPC1MEN1KMT2AEPHX1 | |
| SCHEMBL6866756 | 0.89 | NPC1 (0.56) | RAB9ANPC1MEN1KMT2AEPHX1 | |
| SCHEMBL6874492 | 0.89 | EPHX1 (0.54) | RAB9ANPC1ADRA2AMCHR1EPHX1 | |
| SCHEMBL6874485 | 0.89 | EPHX1 (0.54) | RAB9ANPC1ADRA2AMCHR1EPHX1 | |
| SCHEMBL6876164 | 0.87 | NPC1 (0.47) | RAB9ANPC1MEN1KMT2AADRA2A | |
| SCHEMBL6876167 | 0.87 | NPC1 (0.47) | RAB9ANPC1MEN1KMT2AADRA2A | |
| SCHEMBL6874504 | 0.86 | MCHR1 (0.44) | RAB9AADRA2AMCHR1EPHX1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |