Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 4/20 | 0.52 |
| ▸ | MAOA | P21397 | 2/20 | 0.52 |
| ▸ | CYP4F2 | P78329 | 6/20 | 0.45 |
| ▸ | CYP4A11 | Q02928 | 6/20 | 0.45 |
| ▸ | ACHE | P22303 | 1/20 | 0.45 |
| ▸ | PPARA | Q07869 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.40 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.40 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.38 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.38 |
| ▸ | ANO1 | Q5XXA6 | 2/20 | 0.38 |
| ▸ | MME | P08473 | 1/20 | 0.38 |
| ▸ | ACE | P12821 | 1/20 | 0.38 |
| ▸ | CPA1 | P15085 | 1/20 | 0.38 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6873869 | 0.83 | MAOB (0.51) | MAOBMAOACYP4F2CYP4A11 | |
| SCHEMBL6866132 | 0.81 | MAOB (0.56) | MAOBMAOA | |
| SCHEMBL30792336 | 0.79 | MAOB (0.51) | MAOBMAOACYP4F2CYP4A11ACHE | |
| SCHEMBL11377856 | 0.78 | MAOB (0.56) | MAOBMAOAALOX5 | |
| SCHEMBL16046736 | 0.77 | MAOB (0.47) | MAOBMAOACYP4F2CYP4A11ACHE | |
| SCHEMBL3504417 | 0.77 | P4HTM (0.65) | MAOBMAOACYP4F2CYP4A11PPARA | |
| SCHEMBL226721 | 0.76 | P4HTM (0.59) | MAOBMAOACYP4F2CYP4A11HDAC6 | |
| SCHEMBL7028448 | 0.76 | MAOB (0.67) | MAOBMAOAACHEPPARAHDAC6 | |
| SCHEMBL6873145 | 0.75 | MAOB (0.51) | MAOBMAOACYP4F2CYP4A11ACHE | |
| SCHEMBL30792322 | 0.75 | MAOB (0.50) | MAOBMAOACYP4F2CYP4A11ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1474394-A1 | PYRIDINEAMIDO DERIVATIVES AS INHIBITORS OF MONOAMINE OXIDASE (MAO-B) | F. HOFFMANN-LA ROCHE AG (CH) | 2004-11-10 | — | — | EP | disclosed |
| US-6667327-B2 | Pyridine amido derivatives | HOFFMANN-LA ROCHE INC. | 2003-12-23 | — | — | US | disclosed |
| US-20030158235-A1 | Pyridine amido derivatives | F.HOFFMAN-LA ROCHE AG (CH) | 2003-08-21 | — | — | US | disclosed |
| WO-2003066596-A1 | PYRIDINEAMIDO DERIVATIVES AS INHIBITORS OF MONOAMINE OXIDASE (MAO-B) | F. HOFFMANN-LA ROCHE AG (CH) | 2003-08-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030158235-A1 | Pyridine amido derivatives | MAOB, MAOA, XDH | MAOB 1/4885MAOA 2/4885CYP4F2 918/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.