Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK5 | Q00535 | 7/20 | 0.52 |
| ▸ | CDK5R1 | Q15078 | 7/20 | 0.52 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.46 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.43 |
| ▸ | CHRM3 | P20309 | 4/20 | 0.40 |
| ▸ | DRD2 | P14416 | 2/20 | 0.38 |
| ▸ | DRD4 | P21917 | 1/20 | 0.38 |
| ▸ | DRD3 | P35462 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | HRH1 | P35367 | 1/20 | 0.38 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.38 |
| ▸ | CDK2 | P24941 | 3/20 | 0.38 |
| ▸ | CCNA1 | P78396 | 3/20 | 0.38 |
| ▸ | BCHE | P06276 | 3/20 | 0.36 |
| ▸ | GSK3B | P49841 | 3/20 | 0.36 |
| ▸ | ACHE | P22303 | 2/20 | 0.36 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.36 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5345440 | 0.91 | CDK5 (0.59) | CDK5CDK5R1DYRK1AROCK1CHRM3 | |
| SCHEMBL5342684 | 0.88 | CDK5 (0.62) | CDK5CDK5R1DYRK1AROCK1CCNA2 | |
| SCHEMBL5342417 | 0.87 | CDK5 (0.51) | CDK5CDK5R1DYRK1AROCK1DRD2 | |
| SCHEMBL5345585 | 0.87 | CDK5 (0.51) | CDK5CDK5R1DYRK1AROCK1CCNA2 | |
| SCHEMBL7158859 | 0.87 | CDK5 (0.52) | CDK5CDK5R1DYRK1AROCK1CCNA2 | |
| SCHEMBL5348448 | 0.86 | CDK5 (0.59) | CDK5CDK5R1DYRK1AROCK1CCNA2 | |
| SCHEMBL5348206 | 0.85 | CDK5 (0.49) | CDK5CDK5R1DYRK1AROCK1 | |
| SCHEMBL5354567 | 0.84 | CDK5 (0.54) | CDK5CDK5R1DYRK1AROCK1CCNA2 | |
| SCHEMBL5348886 | 0.84 | CDK5 (0.48) | CDK5CDK5R1DYRK1AROCK1CCNA2 | |
| SCHEMBL5342637 | 0.84 | CDK5 (0.53) | CDK5CDK5R1DYRK1AROCK1CCNA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040039029-A1 | Thiazolyl urea compounds and methods of uses | AMGEN INC. | 2004-02-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040039029-A1 | Thiazolyl urea compounds and methods of uses | SLC14A1, UMPS, BAX | CDK5 64/4885CDK5R1 359/4885DYRK1A 1751/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.