Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | POLB | P06746 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.49 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.48 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.48 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.47 |
| ▸ | CNR1 | P21554 | 1/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
| ▸ | DRD2 | P14416 | 1/20 | 0.46 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.46 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.46 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6867007 | 1.00 | MAPT (0.52) | MAPTALDH1A1POLBKDM4ELMNA | |
| SCHEMBL6875474 | 0.92 | MCHR1 (0.50) | MAPTALDH1A1POLBKDM4ELMNA | |
| SCHEMBL6875466 | 0.92 | MCHR1 (0.50) | MAPTALDH1A1POLBKDM4ELMNA | |
| SCHEMBL6463074 | 0.89 | ALDH1A1 (0.48) | MAPTALDH1A1KDM4ELMNAMCHR1 | |
| SCHEMBL6463067 | 0.89 | ALDH1A1 (0.48) | MAPTALDH1A1KDM4ELMNAMCHR1 | |
| SCHEMBL6458625 | 0.86 | KMT2A (0.45) | MAPTALDH1A1POLBKDM4ELMNA | |
| SCHEMBL6458640 | 0.86 | KMT2A (0.45) | MAPTALDH1A1POLBKDM4ELMNA | |
| SCHEMBL6456655 | 0.84 | AURKB (0.44) | MAPTALDH1A1POLBKDM4ELMNA | |
| SCHEMBL6456663 | 0.84 | AURKB (0.44) | MAPTALDH1A1POLBKDM4ELMNA | |
| SCHEMBL6876727 | 0.84 | SMN1; SMN2 (0.50) | MAPTALDH1A1POLBKDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |