Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 8/20 | 0.50 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.48 |
| ▸ | CNR1 | P21554 | 1/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.48 |
| ▸ | AXL | P30530 | 1/20 | 0.43 |
| ▸ | MERTK | Q12866 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.41 |
| ▸ | HRH1 | P35367 | 2/20 | 0.41 |
| ▸ | HTR2B | P41595 | 2/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.40 |
| ▸ | ERN1 | O75460 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6875466 | 1.00 | MCHR1 (0.50) | MCHR1AURKBCNR1KCNH2AXL | |
| SCHEMBL6867012 | 0.92 | MAPT (0.52) | MCHR1AURKBCNR1KCNH2MAPT | |
| SCHEMBL6867007 | 0.92 | MAPT (0.52) | MCHR1AURKBCNR1KCNH2MAPT | |
| SCHEMBL6875924 | 0.89 | MCHR1 (0.46) | MCHR1AURKBCNR1KCNH2AXL | |
| SCHEMBL6875932 | 0.89 | MCHR1 (0.46) | MCHR1AURKBCNR1KCNH2AXL | |
| SCHEMBL6464781 | 0.87 | MCHR1 (0.51) | MCHR1MAPTLMNAADRA2AHRH1 | |
| SCHEMBL6458011 | 0.87 | HTT (0.47) | MCHR1AURKBCNR1KCNH2ADRA2A | |
| SCHEMBL6458020 | 0.87 | HTT (0.47) | MCHR1AURKBCNR1KCNH2ADRA2A | |
| SCHEMBL6464777 | 0.87 | MCHR1 (0.51) | MCHR1MAPTLMNAADRA2AHRH1 | |
| SCHEMBL6872847 | 0.84 | EPHX2 (0.47) | MCHR1AURKBADRA2AHRH1HTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |