⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL72436 | 0.72 | — | — | |
| SCHEMBL269446 | 0.67 | — | — | |
| SCHEMBL559604 | 0.67 | TP53 (0.38) | — | |
| SCHEMBL27910344 | 0.67 | TP53 (0.53) | — | |
| SCHEMBL5616893 | 0.65 | TP53 (0.39) | — | |
| SCHEMBL28215974 | 0.64 | TP53 (0.36) | — | |
| SCHEMBL6414746 | 0.64 | TP53 (0.37) | — | |
| SCHEMBL27593365 | 0.64 | TP53 (0.37) | — | |
| SCHEMBL7039410 | 0.64 | TP53 (0.37) | — | |
| SCHEMBL8329170 | 0.64 | TP53 (0.37) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 2435 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024022481-A1 | PHENYL-SUBSTITUTED DIHYDRONAPHTHYRIDINE COMPOUNDS, AND PREPARATION AND USE THEREOF | 苏中药业集团股份有限公司 | 2024-02-01 | — | — | WO | claimed |
| CN-113683616-A | KRAS G12C mutein inhibitors | 广州百霆医药科技有限公司 | 2021-11-23 | — | — | CN | claimed |
| CN-113620944-A | Novel RET inhibitors, pharmaceutical compositions thereof and uses thereof | 广东东阳光药业有限公司 | 2021-11-09 | — | — | CN | claimed |
| EP-3894396-A1 | 2-OXOQUINAZOLINE DERIVATIVES AS METHIONINE ADENOSYLTRANSFERASE 2A INHIBITORS | Ideaya Biosciences, Inc. (US) | 2021-10-20 | — | — | EP | claimed |
| CN-110590708-B | Aroyl piperazine compound, preparation method thereof and application thereof in antivirus | 中国医学科学院医药生物技术研究所 | 2021-08-17 | — | — | CN | claimed |
| CN-113166078-A | 2-oxoquinazoline derivatives as methionine adenosyltransferase 2A inhibitors | 伊迪亚生物科学有限公司 | 2021-07-23 | — | — | CN | claimed |
| CN-113121393-A | Aromatic amide compound and application thereof in medicines | 广东东阳光药业有限公司 | 2021-07-16 | — | — | CN | claimed |
| WO-2021136326-A1 | ARYL AMIDE COMPOUND AND APPLICATION THEREOF IN MEDICINE | 广东东阳光药业有限公司 | 2021-07-08 | — | — | WO | claimed |
| US-20210206760-A1 | PHENYL-SUBSTITUTED DIHYDRONAPHTHYRIDINE COMPOUND AND USE THEREOF | SUNSHINE LAKE PHARMA CO., LTD. (CN) | 2021-07-08 | — | — | US | claimed |
| CN-111072571-B | Dithiocarbamates as FAK inhibitors | 北京西博医药研究有限公司 | 2021-05-14 | — | — | CN | claimed |
| WO-2000029398-A1 | ISOTHIAZOLECARBOXYLIC ACID DERIVATIVES | NIHON BAYER AGROCHEM K.K. (JP) | 2000-05-25 | — | — | WO | claimed |
| EP-0985665-A1 | Process for the preparation of 3-amino-2-oxo-pyrrolidines, intermediates and use thereof | Degussa-Hüls Aktiengesellschaft (DE) | 2000-03-15 | — | — | EP | claimed |
| US-6037474-A | Process for the preparation of cyclic 4-oxoamidines | Degussa-Huuls (DE) | 2000-03-14 | — | — | US | claimed |
| EP-0959070-A1 | Process for the production of 3-amino-2-oxopyrrolidines, novel intermediates and their use | Degussa-Hüls Aktiengesellschaft (DE) | 1999-11-24 | — | — | EP | claimed |
| EP-0945441-A2 | Process for the preparation of cyclic 4-oxoamidines | Degussa-Hüls Aktiengesellschaft (DE) | 1999-09-29 | — | — | EP | claimed |
| EP-0832898-A2 | Substituted amino acid derivatives | BAYER AG (DE) | 1998-04-01 | — | — | EP | claimed |
| EP-0825989-A1 | SUBSTITUTED OXAZOLES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1998-03-04 | — | — | EP | claimed |
| WO-1996036617-A1 | SUBSTITUTED OXAZOLES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1996-11-21 | — | — | WO | claimed |
| US-5559150-A | ANTICOAGULANT, ANTITUMOR, ANTIINFLAMMATORY | 3-DIMENSIONAL PHARMACEUTICALS, INC. (US) | 1996-09-24 | — | — | US | claimed |
| WO-1993003033-A1 | CARBONATE-SUBSTITUTED IMIDAZO[4,5-d] PYRIDAZINE COMPOUNDS FOR TREATMENT OF CARDIOVASCULAR DISORDERS | G. D. SEARLE & CO. (US) | 1993-02-18 | — | — | WO | claimed |