Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 3/20 | 0.43 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.41 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.41 |
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | IDH1 | O75874 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.36 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.36 |
| ▸ | ATR | Q13535 | 1/20 | 0.36 |
| ▸ | FAAH | O00519 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4422986 | 0.81 | RXFP1 (0.43) | EPHX2TRPV1POLBLMNAMAPT | |
| SCHEMBL3427239 | 0.79 | EPHX2 (0.65) | EPHX2TRPV1KMT2AMEN1LMNA | |
| SCHEMBL2994541 | 0.79 | EPHX2 (0.47) | EPHX2TRPV1KMT2AMEN1DYRK1A | |
| SCHEMBL22816953 | 0.75 | EPHX2 (0.59) | EPHX2TRPV1KMT2AMAPTL3MBTL1 | |
| SCHEMBL2993681 | 0.75 | L3MBTL1 (0.40) | EPHX2KMT2AMEN1POLBLMNA | |
| SCHEMBL7794191 | 0.73 | CYP17A1 (0.49) | EPHX2KCNQ3KCNQ2TRPV1IDH1 | |
| SCHEMBL31135377 | 0.73 | BRAF (0.47) | EPHX2KCNQ3KCNQ2TRPV1IDH1 | |
| SCHEMBL21268295 | 0.73 | IDH1 (0.39) | EPHX2KCNQ3KCNQ2TRPV1IDH1 | |
| SCHEMBL6754908 | 0.73 | KCNQ3 (0.46) | EPHX2KCNQ3KCNQ2TRPV1IDH1 | |
| SCHEMBL7665668 | 0.73 | KCNQ3 (0.46) | EPHX2KCNQ3KCNQ2TRPV1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1667966-B1 | N-ALKYLATED DIAMINOPROPANE DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | BRISTOL MYERS SQUIBB CO (US) | 2012-02-29 | — | — | EP | disclosed |
| EP-1606255-B1 | CYCLIC DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | BRISTOL MYERS SQUIBB CO (US) | 2009-11-11 | — | — | EP | disclosed |
| EP-2098508-A1 | Cyclic derivatives as modulators of chemokine receptor activity | Bristol-Myers Squibb Company (US) | 2009-09-09 | — | — | EP | disclosed |