Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | MCHR1 | Q99705 | 4/20 | 0.38 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.38 |
| ▸ | HRH1 | P35367 | 2/20 | 0.38 |
| ▸ | HTR2B | P41595 | 2/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.38 |
| ▸ | PARP1 | P09874 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6867225 | 1.00 | HPGD (0.40) | HPGDNPC1RAB9AALDH1A1POLB | |
| SCHEMBL27652861 | 0.87 | HPGD (0.50) | HPGDNPC1RAB9AALDH1A1L3MBTL1 | |
| SCHEMBL27652859 | 0.87 | HPGD (0.50) | HPGDNPC1RAB9AALDH1A1L3MBTL1 | |
| SCHEMBL6872301 | 0.85 | CYP3A4 (0.46) | NPC1RAB9AALDH1A1POLBL3MBTL1 | |
| SCHEMBL6872308 | 0.85 | CYP3A4 (0.46) | NPC1RAB9AALDH1A1POLBL3MBTL1 | |
| SCHEMBL6867296 | 0.85 | MAPT (0.47) | NPC1RAB9AALDH1A1POLBLMNA | |
| SCHEMBL6867305 | 0.85 | MAPT (0.47) | NPC1RAB9AALDH1A1POLBLMNA | |
| SCHEMBL13793345 | 0.83 | MCHR1 (0.57) | HPGDL3MBTL1MCHR1ADRA2AHRH1 | |
| SCHEMBL6461821 | 0.82 | MCHR1 (0.52) | ALDH1A1MCHR1ADRA2AHRH1HTR2B | |
| SCHEMBL6461823 | 0.82 | MCHR1 (0.52) | ALDH1A1MCHR1ADRA2AHRH1HTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100451004-C | Pyrimidine derivatives | ARENA PHARM INC (JP) | 2009-01-14 | — | — | CN | disclosed |
| CN-1798736-A | Novel quinoline, tetrahydroquinazoline and pyrimidine derivatives and methods of treatment related to their use | ARENA PHARM INC (JP) | 2006-07-05 | — | — | CN | disclosed |
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |