Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.45 |
| ▸ | MEN1 | O00255 | 4/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.45 |
| ▸ | PTBP1 | P26599 | 1/20 | 0.45 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.45 |
| ▸ | RELA | Q04206 | 1/20 | 0.45 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 4/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | MCHR1 | Q99705 | 9/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6872301 | 1.00 | CYP3A4 (0.46) | CYP3A4HSD17B10SMN1; SMN2MEN1KMT2A | |
| SCHEMBL6872768 | 0.90 | HSD17B10 (0.48) | CYP3A4HSD17B10SMN1; SMN2MEN1KMT2A | |
| SCHEMBL6872761 | 0.90 | HSD17B10 (0.48) | CYP3A4HSD17B10SMN1; SMN2MEN1KMT2A | |
| SCHEMBL6867305 | 0.90 | MAPT (0.47) | SMN1; SMN2MEN1KMT2ALMNANPC1 | |
| SCHEMBL6867296 | 0.90 | MAPT (0.47) | SMN1; SMN2MEN1KMT2ALMNANPC1 | |
| SCHEMBL6878367 | 0.87 | ADAM17 (0.40) | SMN1; SMN2NPC1RAB9AMCHR1ADRA2A | |
| SCHEMBL6878362 | 0.87 | ADAM17 (0.40) | SMN1; SMN2NPC1RAB9AMCHR1ADRA2A | |
| SCHEMBL6867225 | 0.85 | HPGD (0.40) | LMNANPC1ALDH1A1RAB9AL3MBTL1 | |
| SCHEMBL6867228 | 0.85 | HPGD (0.40) | LMNANPC1ALDH1A1RAB9AL3MBTL1 | |
| SCHEMBL27652859 | 0.85 | HPGD (0.50) | CYP3A4HSD17B10MEN1KMT2ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100451004-C | Pyrimidine derivatives | ARENA PHARM INC (JP) | 2009-01-14 | — | — | CN | disclosed |
| CN-1798736-A | Novel quinoline, tetrahydroquinazoline and pyrimidine derivatives and methods of treatment related to their use | ARENA PHARM INC (JP) | 2006-07-05 | — | — | CN | disclosed |
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |