Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | BCHE | P06276 | 1/20 | 0.43 |
| ▸ | ACHE | P22303 | 1/20 | 0.43 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.40 |
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
| ▸ | MCHR1 | Q99705 | 4/20 | 0.37 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.37 |
| ▸ | HRH1 | P35367 | 2/20 | 0.37 |
| ▸ | HTR2B | P41595 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6867305 | 1.00 | MAPT (0.47) | MAPTTSHRRAB9ASMN1; SMN2NPC1 | |
| SCHEMBL6872308 | 0.90 | CYP3A4 (0.46) | MAPTTSHRRAB9ASMN1; SMN2NPC1 | |
| SCHEMBL6872301 | 0.90 | CYP3A4 (0.46) | MAPTTSHRRAB9ASMN1; SMN2NPC1 | |
| SCHEMBL6878367 | 0.86 | ADAM17 (0.40) | RAB9ASMN1; SMN2NPC1BCHEACHE | |
| SCHEMBL6878362 | 0.86 | ADAM17 (0.40) | RAB9ASMN1; SMN2NPC1BCHEACHE | |
| SCHEMBL6867225 | 0.85 | HPGD (0.40) | MAPTRAB9ANPC1PARP1MCHR1 | |
| SCHEMBL6867228 | 0.85 | HPGD (0.40) | MAPTRAB9ANPC1PARP1MCHR1 | |
| SCHEMBL13793464 | 0.83 | MCHR1 (0.56) | PARP1MCHR1ADRA2AHRH1HTR2B | |
| SCHEMBL7043623 | 0.82 | MCHR1 (0.44) | MCHR1ADRA2AHRH1HTR2BADRA1A | |
| SCHEMBL7043626 | 0.82 | MCHR1 (0.44) | MCHR1ADRA2AHRH1HTR2BADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |