Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RY1 | P47900 | 3/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.40 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.40 |
| ▸ | MCHR1 | Q99705 | 5/20 | 0.40 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.39 |
| ▸ | CDK2 | P24941 | 1/20 | 0.39 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | CDK7 | P50613 | 1/20 | 0.39 |
| ▸ | CDK9 | P50750 | 1/20 | 0.39 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6867237 | 1.00 | P2RY1 (0.49) | P2RY1KDM4ETDP1LMNAMAPK8 | |
| SCHEMBL6878016 | 0.91 | EPHX2 (0.45) | P2RY1TDP1MAPK14MCHR1CYP2C9 | |
| SCHEMBL6878023 | 0.91 | EPHX2 (0.45) | P2RY1TDP1MAPK14MCHR1CYP2C9 | |
| SCHEMBL6460789 | 0.89 | MCHR1 (0.42) | P2RY1KDM4ETDP1MAPK8MAPK14 | |
| SCHEMBL6460783 | 0.89 | MCHR1 (0.42) | P2RY1KDM4ETDP1MAPK8MAPK14 | |
| SCHEMBL6872853 | 0.87 | EPHX2 (0.47) | MAPK8AURKBMAPK14MCHR1MEN1 | |
| SCHEMBL6872847 | 0.87 | EPHX2 (0.47) | MAPK8AURKBMAPK14MCHR1MEN1 | |
| SCHEMBL6869279 | 0.86 | MAPK14 (0.54) | MAPK8AURKBMAPK14MCHR1HTT | |
| SCHEMBL6878450 | 0.86 | MAPK8 (0.41) | KDM4EMAPK8AURKBMAPK14MCHR1 | |
| SCHEMBL6869275 | 0.86 | MAPK14 (0.54) | MAPK8AURKBMAPK14MCHR1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |