Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Nitric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FNTA | P49354 | 1/20 | 0.59 |
| ▸ | FNTB | P49356 | 1/20 | 0.59 |
| ▸ | CYP19A1 | P11511 | 12/20 | 0.48 |
| ▸ | CNR1 | P21554 | 4/20 | 0.45 |
| ▸ | CYP17A1 | P05093 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | PGR | P06401 | 1/20 | 0.42 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | IDO1 | P14902 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | MAOA | P21397 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6867606 | 0.82 | FNTA (0.67) | FNTAFNTBCYP19A1CNR1CYP17A1 | |
| SCHEMBL6869798 | 0.80 | FNTA (0.61) | FNTAFNTBCYP19A1CNR1CYP17A1 | |
| Nitric Acid SCHEMBL6873528 | 0.79 | FNTA (0.58) | FNTAFNTBCYP19A1CNR1CYP17A1 | |
| Nitric Acid SCHEMBL6873533 | 0.79 | FNTA (0.58) | FNTAFNTBCYP19A1CNR1CYP17A1 | |
| SCHEMBL6868055 | 0.75 | FNTA (0.63) | FNTAFNTBCYP19A1CNR1CYP3A4 | |
| Nitric Acid SCHEMBL9523951 | 0.74 | CYP19A1 (0.53) | FNTAFNTBCYP19A1CNR1CYP17A1 | |
| SCHEMBL6303535 | 0.74 | FNTA (1.00) | FNTAFNTBCYP19A1CNR1CYP17A1 | |
| SCHEMBL6310693 | 0.73 | FNTA (0.67) | FNTAFNTBCYP19A1CNR1CYP17A1 | |
| SCHEMBL6869878 | 0.73 | FNTA (0.50) | FNTAFNTBCYP19A1CNR1CYP17A1 | |
| Oxalic Acid SCHEMBL7701815 | 0.70 | FNTA (0.49) | FNTAFNTBCYP19A1CNR1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1106610-B1 | Farnesyl transferase inhibiting 2-quinolone derivatives | JANSSEN PHARMACEUTICA NV (BE) | 2004-06-16 | — | — | EP | disclosed |
| EP-1019395-B1 | FARNESYL TRANSFERASE INHIBITING 2-QUINOLONE DERIVATIVES | JANSSEN PHARMACEUTICA NV (BE) | 2002-01-30 | — | — | EP | disclosed |
| EP-1106610-A1 | Farnesyl transferase inhibiting 2-quinolone derivatives | Janssen Pharmaceutica N.V. (BE) | 2001-06-13 | — | — | EP | disclosed |
| EP-1019395-A1 | FARNESYL TRANSFERASE INHIBITING 2-QUINOLONE DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 2000-07-19 | — | — | EP | disclosed |
| US-5968952-A | ANTITUMOR AGENTS | JANSSEN PHARMACEUTICA, N.V. (BE) | 1999-10-19 | — | — | US | disclosed |
| WO-1997016443-A1 | FARNESYL TRANSFERASE INHIBITING 2-QUINOLONE DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 1997-05-09 | — | — | WO | disclosed |