Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 7/20 | 0.57 |
| ▸ | MCHR1 | Q99705 | 7/20 | 0.57 |
| ▸ | LMNA | P02545 | 3/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.53 |
| ▸ | HRH1 | P35367 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | HTR1A | P08908 | 1/20 | 0.46 |
| ▸ | HTR2B | P41595 | 1/20 | 0.46 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.46 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6867248 | 1.00 | ADRA2A (0.57) | ADRA2AMCHR1LMNAKDM4ESMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL6459511 | 0.99 | ADRA2A (0.56) | ADRA2AMCHR1LMNAKDM4ESMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL6459506 | 0.99 | ADRA2A (0.56) | ADRA2AMCHR1LMNAKDM4ESMN1; SMN2 | |
| SCHEMBL6460116 | 0.92 | ADRA2A (0.67) | ADRA2AMCHR1LMNAKDM4ESMN1; SMN2 | |
| SCHEMBL6460123 | 0.92 | ADRA2A (0.67) | ADRA2AMCHR1LMNAKDM4ESMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL6455250 | 0.91 | ADRA2A (0.66) | ADRA2AMCHR1LMNAKDM4ESMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL6455255 | 0.91 | ADRA2A (0.66) | ADRA2AMCHR1LMNAKDM4ESMN1; SMN2 | |
| SCHEMBL6461614 | 0.87 | MCHR1 (0.61) | ADRA2AMCHR1LMNAADRA1AHRH1 | |
| SCHEMBL6461619 | 0.87 | MCHR1 (0.61) | ADRA2AMCHR1LMNAADRA1AHRH1 | |
| SCHEMBL6458000 | 0.87 | LMNA (0.59) | ADRA2AMCHR1LMNAKDM4ESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |