Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MCHR1 | Q99705 | 9/20 | 0.42 |
| ▸ | ADRA2A | P08913 | 6/20 | 0.42 |
| ▸ | HRH1 | P35367 | 3/20 | 0.42 |
| ▸ | HTR2B | P41595 | 3/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | IDH1 | O75874 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6867278 | 1.00 | ALDH1A1 (0.43) | ALDH1A1KDM4EMCHR1ADRA2AHRH1 | |
| SCHEMBL6867788 | 0.93 | MCHR1 (0.42) | ALDH1A1MCHR1ADRA2AHRH1HTR2B | |
| SCHEMBL6867783 | 0.93 | MCHR1 (0.42) | ALDH1A1MCHR1ADRA2AHRH1HTR2B | |
| SCHEMBL6869284 | 0.88 | KMT2A (0.47) | ALDH1A1MCHR1ADRA2AHRH1HTR2B | |
| SCHEMBL6869288 | 0.88 | KMT2A (0.47) | ALDH1A1MCHR1ADRA2AHRH1HTR2B | |
| SCHEMBL6875135 | 0.88 | MCHR1 (0.41) | ALDH1A1MCHR1ADRA2AHRH1HTR2B | |
| SCHEMBL6875129 | 0.88 | MCHR1 (0.41) | ALDH1A1MCHR1ADRA2AHRH1HTR2B | |
| SCHEMBL6874359 | 0.88 | MCHR1 (0.48) | MCHR1ADRA2AHRH1HTR2BADRA1A | |
| SCHEMBL6874353 | 0.88 | MCHR1 (0.48) | MCHR1ADRA2AHRH1HTR2BADRA1A | |
| SCHEMBL6868128 | 0.88 | MCHR1 (0.46) | ALDH1A1MCHR1ADRA2AHRH1HTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |